| objective: The role of PORT for radical resected ESCC remains controversial.This meta-analysis aims to determine whether PORT achieves survival benefit compared with surgery alone for radically resected ESCC.Methods: The Pub Med,EMBASE,Web of Science,and Cochrane Library were searched for relevant articles.All publications were screened by the inclusion and exclusion criteria strictly,then we undertake the quality assessment and data abstraction,finally the meta analysis were performed by using the Revman5.3 or the Stata14.0.The reliability of results were evaluated by sensitivity analysis and publication bais analysis.The primary endpoints were OS and DFS.Results: 6 randomized trials and 13 retrospective studies that included a total of 8198 patients were eligible.PORT provided significant OS benefit compared with surgery alone in retrospective studies(HR = 0.75,95% CI: 0.65-0.85),but not in RCTs(HR =0.94,95% CI: 0.81-1.09).PORT was associated with significantly improved DFS and obvious reduction in the risk of locoregional recurrence compared to surgery alone in either retrospective studies or RCTs.In the subgroup analysis for retrospective studies,PORT gained superior OS in patients with lymph node-positive(p N+),patients with lymph node-negative(p N0)or p T2-3N0,PORT with three-dimensional radiotherapy(3D-RT),PORT with chemotherapy,and patients with R0 resection,respectively.Conclusion:PORT can improve DFS in patients with radically resected ESCC.PORT can decrease risk of locoregional recurrence in patients with radically resected ESCC. |
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