| Objectives To elucidate the roles of mammalian target of rapamycin (mTOR) on the vulnerability of atherosclerotic plaques in patients with different types of coronary artery disease.Methods:Twenty patients with acute myocardial infarction (AMI),20 patients with unstable angina pectoris (UAP),20 patients with stable angina pectoris (SAP) and twenty patients with chest pain syndrome (CPS) underwent the study. Coronary arteriography (CAG) was performed in all patients. Concentrations of mTOR were measured by means of Enzyme-Linked-Immonosorbent Assay (ELISA). mRNA expression levels of mTOR in the monocytes were measured by RT-PCR.Results:Concentrations of mTOR were significantly higher in AMI and UAP patients than those of patients in SAP and the CPS (P＜0.05～0.01), but there was no significant difference between AMI group and UAP group. mRNA expression levels of mTOR in patients with AMI and UAP were significantly higher than those of patients in SAP and the control groups (P<0.05).Conclusions:The mTOR was associated with coronary plaque vulnerability. |
