| ObjectiveTo clarify the risk factors leading to the isolated Congenital Microtia, a systematic review was launched by using software STATA 12.0 based on related study.MethodsPublications about related risk factors of isolated congenital microtia were totally indexed, 11 papers were selected, the table of basic characteristics and the form of statistics analysis was built by using Microsoft EXCEL. And the latter one was included into the data pool of software STATA 12.0. The combined odds ratio (OR), which was used as standard effect index, was calculated and its corresponding 95% confidence interval (95%CI)was also adopted at the same time, random effect model was applied to export Forest Plot to present the results visually, heterogeneity was evaluated by related index. Finally, appropriate funnel plot combined with begg’s and egger’s test were implemented in order to evaluate publication bias.Result10 literatures were included for Meta-analysis based on the standard of exclusion. The following risk factors had significant difference:,The combined OR and 95%CI were respectively as follows, multiple birth [1.72 (1.22,2.41)],smoking[1.44(1.02,2.05)],alcohol consumption [2.73(1.52,4.88)],high maternal age[2.73(1.52,4.88)]. On the contrary, maternal diabetes, hypertension, abortion, low maternal education level, folic acid usage bear no significant relationship with isolated congenital microtia.Conclusion:Risk factors associated with isolated congenital microtia were multiple birth, maternal smoking, maternal alcohol consumption and high maternal age. |
