Vitamin D With Or Without Calcium Supplementation For Prevention Of Osteoporosis Fractures In Elderly Person Systematic Review

Objective:To assess the effects of Vitamin D alone and combined vitamin D and calcium supplementation for prevention of osteoporosis fractures in elderly people by systematic review.Methods:We searched for randomized controlled trials (RCTs) in the following electronic databases:MEDLINE (1992～December 2014), EMBASE(1992-December 2014), The Cochrane library (1992～December 2014), CBM(1992～ December 2014), CNKI(1992～December 2014).We also hand searched Chinese orthopaedic magazines. This analysis was performed with software RevMan 5.3 from the Cochrane collaboration.Results:From 81 literatures,we identified 24 relevant randomized controlled trials with a total of 141047 participants. The results of meta-analysis:Both vitamin D and vitamin D with calcium prevent osteoporosis fractures without affecting or increasing mortality:RR=1.24 (95%CI=0.91～1.70,P=0.18) vs RR=1.05 (95%CI=0.97-1.13,P=0.27). It is reported that the incidence of combining vitamin D treatment vs control was not obviously advantage; the incidence of vitamin D and calcium treatment vs control was statistically significant difference.Among them, vitamin D treatment vs control,data analyzing:RR=0.90 (95%CI=0.82 ～0.98,P=0.02); vitamin D and calcium treatment vs control,data analyzing RR=0.97(95%CI=0.89～1.04,P=0.38). The treatment group of serum 25-hydroxyvitamin D concentration is better than control group.Conclusions:vitamin D alone or combined vitamin D and calcium to prevent osteoporosis fractures did not increase mortality, combining vitamin D and calcium can reduce osteoporosis fractures in elderly person,vitamin D treatment is not obviously advantage...