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Comparation Of Curative Effects For Esophageal Varices With Endoscopic Sclerotherapy And Surgical Disconnection Operation

Posted on:2016-02-21Degree:MasterType:Thesis
Country:ChinaCandidate:J WangFull Text:PDF
GTID:2284330461465350Subject:Digestive internal medicine
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Objective:Compare the curative effects of esophageal varices with EVS and SD operation.Methods:Clinical data from esophageal varices patients with EVS and SD from January 1,2009 to December 31,2013 was collected. The incidence of rebleeding, time of rebleeding, time of survival were followed up. The data was statistically analyzed.Results:50 cases were with EVS treatment and 80 cases were with SD treatment.113 cases were male and the rest 17 cases were female.The average age of EVS group was 48.80±10.89 (age), and that of SD group was 43.24± 10.91 (age); Viral hepatitis was the main cause resulting in hepatic cirrhosis (99/130,76.15%); 56 cases were with Child-Pugh A grade and 68 cases were with Child-Pugh B grade; The severe esophageal varices were 121 cases. The average time of hospitalization for EVS group was shorter than SD group (11.62±6.59 days vs 29.81±13.69 days, P=0.001). The average total hospital costs was less expensive for EVS group than SD group (37166±26650.30 yuan vs 50960±27592.15 yuan,p=0.006).The average number of hospitalization and EVS treatment aslo increased in EVS group than SD group (2.10±1.31 times vs 1.00±0.00 time; 2.76±1.20 times vs 1.00±0.00 time, all p<0.05). The average interval time of EVS group was 38.71±5.67 days. EVS group:20 patients were rebleeding (40.00%), and 13 patients were dead (26.00%). SD group:17 patients were rebleeding (21.25%), and 12 patients were dead. Statistically significant in rebleeding rate between EVS group and SD group was observed (P=0.021), but no significant diffrence about mortality rate between two groups was observed. The average rebleeding time of EVS group was earlier than SD group (38.65±4.00m vs 55.99±3.01m, P=0.002), and the average survival time of EVS group was shorter than SD group (46.69±3.54 m vs 60.48±2.67 m, P=0.041). At Child-Pugh A grade:No significant diffrence about rebleeding rate, mortality rate, average time of rebleeding and that of survival was observed between two groups. At Child-Pugh B grade:The rebleeding rate of EVS group was significantly higher than that of SD group (46.67% vs 23.68%, P=0.047). The average time of rebleeding was significantly earlier in EVS group than that in SD group (26.35±3.64m vs 56.21±3.85m, P=0.001). Howerver, there was no significant difference about mortality rate and average time of survival between two groups. EVS group: According to liver function, Child-Pugh A, Child-Pugh B, Child-Pugh C were divided into three groups. No significant difference about average time of rebleeding among three groups was observed. Average time of survival in Child-Pugh A group and Child-Pugh B group was significantly longer than that in Child-Pugh C group (58.31±3.55 m vs 43.18±4.01m vs 17.80±6.06m, P=0.004). SD group:No significant difference about average time of rebleeding and of survival was observed between Child-Pugh A group and Child-Pugh B group.Conclusions:At Child-Pugh A grade, there was no sinificant diffrence of the average time of rebleeding between EVS group and SD group; However, at Child-Pugh B grade, the average time of rebleeding was significantly earlier in EVS group than that in SD group; No significant difference in the average time of survival between EVS group and SD group was observed; The total hospital costs was less expensive for EVS group than SD group.
Keywords/Search Tags:esophageal varices, sclerotherapy, disconnection operation, rebleeding, secondary prevention
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