| Objective: In this experiment pregnant women are the subjects. We will calculate the incidence of all kinds of pregnancy-related thyroid disease, analyze the relationship between different thyroid disease and pregnancy hypertension, miscarriage, premature delivery, placental abruption and other adverse complications, estimate the benefits of drug treatment for different types of thyroid dysfunction, explore the relationship between serum TSH,FT4,TPOAb levels and women age, education, ethnicity etc. We will also discuss the current status of the treatment of thyroid disease during pregnancy and accumulate the relevant data and clinical experience.Methods:1. Select the Gansu Maternal and Child Health Hospital’s documented pregnant women in April 2013 to October 2013 as research subjects. Their first thyroid function results during pregnancy were collected. According to the results, divided them into normal control group and thyroid dysfunction group. Except euthyroid woman, the women who have thyroid dysfunction were given interventions. According to the degree of adherence to treatment, they were divided into the treatment group and the observation group. Based on statistical principles, normal control group were randomly selected from healthy pregnant women. The thyroid function of all subjects was monitored regularly till delivery.2. After delivery, analyze the incidence of adverse pregnancy outcomes in each group, and try to identify the possible association between adverse outcomes and thyroid dysfunction, and evaluate the effect of medication on thyroid dysfunction. Collect the neonatal hypothyroidism screening results and examine results in each group. Analyze the relationship between thyroid dysfunction and newborn thyroid function.Results:1. The study included 240 pregnant women, the maximum age was 44 years old, the minimum age was 18 years old, and the average age was 28.3 years. Subjects had their initial inspection during different phases of pregnancy,42 had the inspection during early pregnancy,161 in second trimester and 37 in late pregnancy. Five of them have a family history of thyroid disease. The ethnicity of 219 participants are Han.2. According to the initial inspection of thyroid function in pregnant women, the result shows that there are 182 subjects with normal thyroid function. Among those women who have abnormal thyroid function, there are 3 subjects with overt hypothyroidism, the prevalence was 1.25%, 13 subjects with subclinical hypothyroidism, the prevalence of 5.42%, 3 subjects with overt hyperthyroidism, the prevalence was 1.25%, 4 subjects with subclinical hyperthyroidism, the prevalence was 1.67%, 13 subjects with hypothyroxinaemia, the prevalence was 5.42%, and 22 subjects with positive TPOAb, the prevalence was 9.17%.3. In the end of pregnancy, the statistical analysis showed that for the normal women, the TSH levels tended to increase from the beginning of pregnancy to delivery, while the FT4 and TPOAb levels tended to decrease. In Subclinical hypothyroidism’s treatment group, the serum TSH levels and TPOAb levels are lower than the levels of the observation group, but no significant difference was found between the treatment group and the control group.4. No significant difference was found between the incidences of adverse effects of subclinical hypothyroidism group, hyperthyroidism group and hypothyroxinaemia group. But in TPOAb positive group, the incidence of gestational hypertension in observation group was significantly higher than the control group, the difference was statistically significant (P<0.05).Conclusions:1. The percentage of pregnant women who showed a positive TPOAb result reached 9.17%, and the increased TPOAb was found to be associated with the higher incidence of gestational hypertension.2. Pregnant women with hyperthyroidism or hypothyroidism should receive medication treatment to reduce the risk of adverse pregnancy complications.3. Thyroid function screening tests are essential for pregnant women and fetus. |
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