FSGS Of Renal Intensive Care Unit:the Cause Of Hospitalization And The Clinical Characteristics

Objective:To analyze the cause of hospitalization and the clinical characteristics of FSGS patients who visited to the renal intensive care unit(RICU).Methodology:We selected patients with FSGS who visited to the RICU from July 2009 to December 2012, analyzed in the reasons for such patients stay RICU,clinical characteristic and prior treatment.Results:1) The study included 48 cases of FSGS patients, including 36 males and 12 females, accounting for all RICU hospitalized patients (a total of 1626 cases) of 2.93%, accounting for nephrotic syndrome (a total of 153 cases) of 31.37%, median age 23 years, median duration of 5.2 months kidney disease,42 cases (87.5%) patients with proteinuria> 3.5g/d.2) 23 cases (47.9%) of admissions were associated with major infections, pneumia (9 cases,39.1%), and skin and soft tissue infections (6 cases,26.1%) were the most common infection,patients who suffered longer kidney disease and were not sensitive to glucocorticoid therapy were more inclined to infection. According to the patients with and without infection were divided into infection group (23 cases) and non infection group (25 cases). Compared with non-infected patients, infection in patients longer course (August VS 1.5 months, P<0.05), corticosteroids and cytotoxic drugs usage rate (corticosteroids:95.8% VS 63%, P< 0.05; cytotoxic drugs:43.5% VS 16%, P<0.05).3)31 cases (64.4%) patients with acute kidney injury (AKI),1 stage,2 and 3 each 10,9 and 12 cases, including 19 patients (61.3%) patients with onset of hypovolemia,14 patients (45.2%) patients the initial onset and no use of corticosteroids and cytotoxic drugs, or just accept the above medications (newly diagnosed de novo). According to the patients with and without AKI divided into AKI group (31 cases) and non AKI group (17 cases). Compared with non-AKI patients, AKI patients Steroid resisters lower proportion (16.1% VS 52.9%, P<0.05), the use of cytotoxic drugs and low (19.4% VS 47.1%, P<0.05), while glucocorticoid usage no difference.4) 26 cases (54.2%) patients with electrolyte disorder, including 14 cases of hypokalemia,16 cases of hyponatremia. Infection, AKI and electrolyte disorders often overlap exists,12 cases of infection with AKI,14 cases of infection combined electrolyte disorder,16 cases of AKI combined electrolyte imbalance, while seven cases of infection, AKI and electrolyte disorderConclusion:Infection, AKI and electrolyte imbalance were the main admissions of FSGS patients hospitalized in renal intensive care unit, the three often overlap existed. High rate of infection in patients with Steroid resistance, pneumia, skin and soft tissue infections were the most common infection,use of glucocorticoid and/or cytotoxic drugs were risk factors for infection. High incidence of acute kidney injury in patients with newly diagnosed de novo, where the presence of renal hypoperfusion factor in the majority of patients.