Evaluation Of Curative Effect Of Biliary Stent Combined With ¹²⁵I Particles For Intracavitary Treatment Of Malignant Jaundice In Cholangiocarcinoma

ObjectiveTo investigate the difference of clinical curative effects of percutaneous biliary metal stent and stent combined with 125 I particles for intracavitary irradiation treatment of malignant jaundice in cholangiocarcinoma.Methods52 patients with malignant obstructive jaundice caused by cholangiocarcinoma which was unsuitable for radical cure operation were selected. The stents was performed at first,then they were divided into in treatment group(26 cases) and control group(26 cases) according to the implantation of 125 I particle. Compare the routine biochemistry, tumor maximum diameter, minimum diameter, and jaundice time, survival time of two groups if there are statistically significant before and after treatment.ResultsThe liver functions in two groups were improved significantly compared with preoperative liver functions after treatment for 1, 3, 6months, and the difference was statistically significant(P<0.05); There was no significant difference in postoperative bilirubins in two groups(P>0.05);Significant differences in bilirubin levels were observed between groups as follows: liver functions of patients are different in preoperative 3 and 6months after treatment and preoperative; postoperative 3 months and 1month after treatment; and postoperative 6 months and 3 months after treatment in two groups,and the differences were statistically significant(P<0.05); The tumor size significantly reduced in treatment group after treatment, while the tumor size in control group significantly increased,and the difference was statistically significant(P<0.05). The average survival time was(12.83±1.57) months and the 24 month survival rate was38.46% in treatment group; while the average survival time was(8.89±1.0)months and the 24 month survival rate was 11.54% in control group,and the difference was statistically significant(P<0.05).ConclusionCompared with simple stent implantation therapy, intracavitary irradiation therapy with percutaneous biliary metal stent combined with 125 I particles had the same effect of reducing jaundice. Meanwhile it could effectively inhibit tumor growth and prolong the survival of patients and stent latency time. Furthermore, the inside source type is conducive to recycling more conveniently to observe the curative effect and adjust the particle position, additional therapeutic dose, and radioactive materials.