Clinical Studies Of Dangguibuxue Decoction Treatment On Non-Proliferative Diabetic Retinopathy

Objective:To observe the efficacy of the Dangguibuxue decoction to the improvement of visual acuity, ocular fundus, TCM syndrome and evaluate the clinical efficacy and safety of drug in patients with non-proliferative diabetic retinopathy(NPDR) of the blood deficiency and collaterals resistance type.Methods:A randomized open drug control methods. A total of 129 case NPDR of blood deficiency and collaterals resistance type come from the sendocrinology outpatient and inpatients of our hospital.They are randomly divided into two groups, experimental group 67 cases accepted Dangguibuxue decoction (10ml tid),and the 62 patients of control group received calcium capsules Dobesilate (0.5g tid). Meanwhile, all subjects were given the lifestyle intervention, hypoglycemic, antihypertensive and lipid-lowering therapyduring the test. And we investigate the differences of visual acuity, ocular fundus(by fundus photography, fundus fluorescein angiography observed the changes of microvascular tumor, bleeding, exudation), TCM syndrome and other therapeutic indexes between the tow groups; Meanwhile, we observe the changes in blood sugar, blood pressure, lipids and other general indexes before and after the test. And we evaluate the safety of drugs by assessing the changes in blood, liver function, kidney function and other safety indexes of subjects.Results:1) After 12 weeks of treatment, both groups TCM symptom scores were significantly decreased (P<0.05), the test group decreased from 12.33±4.13 to 7.33 ±4.54, a total of 48 cases of effective and total efficiency 74.6%, The control group decreased from 11.2 ± 3.33 to 8.65±2.98, a total of 33 cases effective, the total efficiency 57.89%.Experimental group was superior to the control group, the difference was statistically significant(P<0.05).2) After 12 weeks of treatment, combined with visual acuity, fundus (fundus photography, fundus fluorescein angiography) statistical total effect, The experimental group was 41 cases effective, the total efficiency was 65.08%,in the control group 35 cases, the total efficiency was 61.40%, the difference was not statistically significant effect (P> 0.05).In terms of improve vision, the experimental group increased from 0.93±0.23 to 1.01±0.23, the total efficiency of 44.44%; control group increased from 0.91±0.24 to 0.97±0.29, the total efficiency of 42.11%, the difference was not statistically significant effect (P> 0.05).In terms of improving the fundus(Reduce microvascular tumor, bleeding, exudation), in the experimental group, the total efficiency of 39.68%, in the control group, the total efficiency of 39.68%, the difference was not statistically significant effect (P> 0.05).3) Before and. after treatment, blood routine, liver function, kidney function and other key indicators (WBC, NE, ALT, AST, BUN, CRE, UA) are controlled within the normal range. There were no significant differences between groups. Serious adverse events did not occur during the test groups.Conclusion:1)Dangguibuxue decoction can improve the TCM syndrome NPDR of the blood deficiency and collaterals resistance type, more effective than calcium dobesilate.2) Dangguibuxue decoction can improve vision, improve capillary hemangioma, hemorrhage, exudation retinopathy in patients with NPDR of the blood deficiency and collaterals resistance type, he efficacy was no significant difference with Dobesilate calcium.3) Dangguibuxue decoction treatment NPDR of the blood deficiency and collaterals resistance type is effective and safety.