A Retrospective Clinical Analysis Of The53Hospitalized Drug Eruption Patients At Dermatology Of Ningxia Medical University In Last Five Years

Purpose: Provide the reference and improve the clinical secure and rational drug use forfollowing drug eruption treatment work through the synthetically analysis of the clinical data,and the summary of the related drug type and drug eruption.Method:Through retrospective andstatistical analysisof the53hospitalized patients withdrug eruption at Dermatology of General Hospital of Ningxia Medical University fromOctober of2008to October of2013, summarize the basic information, sensitizing medicines,incubation period, clinical manifestation, laboratory check, treatment, prediction and etc. withSPSS18.0and Excel charts.Result:Among53drug eruption patients,27male cases [50.9%], female26cases[49.1%], male and female ratio1:1.04; average onset age [36.06±18.67], most of the patientage scattered between21and5; the majority is farmer patient15[28.3%]; average onsetperiod[2.87±3.80](1) the longest onset period is15days with herbal treatment, the shortestonset period is0.67±0.58day with medicine on digestive system.(2)Eczematous drugeruption has shortest onset period (1.2±0.84day), purpuric drug eruption has the longest onsetperiod (7.5±3.54days).(3)nonsevere drug eruption onset period is2.82±3.85day, averageonset period of the severe drug eruption group is3.87±3.51day, the variance between twogroup is not significant (P>0.05); sensitizing drug in herbal medicine is17(32.1%), amongwhich the majority is antipyretic analgesics9(17%); the most common drug eruption ismeasles32cases (60.4%), the following is erythema multiforme6cases (11.3%); fever16 cases (30.2%), high WBC22cases (41.5%), ALT or AST13cases (24.5%),2cases werehelpful to detect HIE in full-term neonates and evaluate the extent of brain injury.diagnosed as rug induced liver injury、urine protein positive14cases (26.4%), uricbravery former positive10cases(18.9%), protein metabolic abnormal23cases (43.4%),average hospitalized period is9.17±4.12days, the fixed drug eruption type has shortesthospitalization period6±2.83day,34cases (64.1%) of hormone users are treated withglucocorticoids treatment, supported with stomach protection, liver protection, calciumsupplement, potassium supplement and etc. The non-hormone users are treated withCompound Glycyrrhizin, vitamin C, Calcium gluconate, antihistamine drug, and etc. All thepatients stopped using any sensitizing medicine and treated with corresponding supportivetreatments based on the treatments explained above. The total effective rate is98.1%except1checked out oneself.Conclusion:(1) The morbidity of drug eruption cases has no significant difference, could be observedin any age rage.(2) The measles is the most commonly observed drug eruption type; the eruption causedby antipyretic analgesics, Cephalosporin and Penicillin are relatively common, eruptioncaused by herbal medicine and Chinese patent drugs are rising.(3) The same type of medicine may cause differing drug eruption type, and the sameeruption type also may be caused by differing drug.(4) Low protein, high WBC, and liver damage are regularly observed among drugeruption patients.(5) Glucocorticoidsis still the crucial and best choice at the early stage of treatments,compound glycyrrhizin is found effective in the treatments.