Clinical Analysis Of59Systemic Lupus Erythematosus In Children

Part I: Initial manifestation of systemic lupus erythematosus of childrenObjective To calculate percentage of initial manifestation of systemic lupuserythematosus of children to improve the diagnostic rate. Methods Carry outretrospective analysis of (January2002-January2012)59cases of hospitalized childrenwith SLE, to sort initial manifestation and related test, and examination results. Resultsthe most common initial manifestation of children with systemic lupus erythematosus (SLE)is mucocutaneous symptom (66.10%), other manifestations such as persistent fever(37.29%) and fatigue (27.12%), and muscle and joint pain (30.51%), facial or leg edema(25.42%),etc. Convulsions are uncommon. Conclusion The reasons of children withsystemic lupus erythematosus (SLE) for doctor are usually multiple lines of red facial rash,local pigmentation, or color change of cold hands, and typical butterfly rash and discoidrash are uncommon. Sustained fever with unknown reason and historic fatigue often occur,the symptoms paid more attention mainly focused on the pain in large joints and limbs, andswelling of eyelids,face or both lower limbs. A minority of children may have variousacute symptoms.Part II: Clinical characteristics of children with systemic lupus erythematosus.Objective To investigate the clinical characteristics in the courses of children withsystemic lupus erythematosus, and to provide basis for improving of clinical diagnosis andtreatment of disease. Methods Carry out retrospective analysis (January2002-January2012) of59cases of hospitalized children with SLE, sort abnormal and positive clinicalmanifestations and examination results in the processes of onset, hospitalization, andpost-treatment. Results For children, SLE often occur in the age of puberty, fever and rash are the most common clinical manifestations, organ and system damage often occur inthe kidneys and blood systems,and abnormal immunological parameters such asanti-dsDNA(74.58%), and ANA antibody are higher. Except for CRP, the various indicatorshave no difference between men and women. Conclusion Children with unexplainedfever and rash, if a variety of autoantibodies spectrum abnormal or multiple systemdamage exist,should be wary of the possibility of systemic lupus erythematosus.Part III: SLEDAI scores and efficacy assessments of children with SLE before andafter treatmentObjective To analyze changes in clinical symptoms before and after treatment ofchildren with SLE, and determine efficacy. Methods Hospitalize the above59children inour hospital for regular treatment, wherein the children with complete return visit databefore and after hospitalization were included into the study, so a total of11eligiblepatients were subject to examination of related clinical manifestations before and aftertreatment. Statistics of the examination results and parallel SLEDAI scoring wereperformed, and the results before and after treatments were subject to comparison. ResultsAfter regularly using corticosteroids and (or) immunosuppressive therapy, SLEDAI scoresof all patients were somewhat lower than the scores of onset, and clinical symptoms andabnormal indicators were reduced. Conclusion Glucocorticoids and (or)immunosuppressive therapy for controlling the disease and improve the prognosis of SLE.