An Analysis Of Serum Lipid In Pregnant Women Of Different Gestational Age And Of Different Glycemic States

Objective To understand the fluctuations in the serum lipid profile of pregnant womenin different gestational age and in different glycemic states and of women after the completionof pregnancy..Methods Continuously collected patient-cases from January2013to December2013in Ningxia Medical University General hospital. Four hundred and thirty-three pregnantwomen were recruited and divided into2groups (according to the American ADA standards):normal pregnant women (NGRG) group of315cases, pregnant women with gestationaldiabetes (GDM) group of118cases. We excluded pre-pregnancy impaired glucose tolerance,diabetes, hypertension and other endocrine and metabolic diseases, ruled out alcohol addiction.Two groups of pregnant women were questionnaires and tested basic laboratory tests: serumlipid profile, fasting blood glucose, postprandial blood glucose1hour,2hours after the meal,three hours after a meal, blood pressure, serum creatinine, blood urea nitrogen, albumin andthen we analyze statistics.Results (1) Compared normal pregnancy group (NGRG group) and gestationaldiabetes mellitus (GDM group) of clinical data: GDM group was significantly higher thanNGRG group with gestational diabetes age, prepregnancy BMI and ponderal growth duringpregnancy. There were significant differences between the two groups, clinical datacomparing the two groups was statistically significant (P <0.05).(2) The general clinicalfeatures between two groups: GDM group was significantly higher than NGRG SBP group,with statistical significance (P <0.05); GDM group albumin levels were significantly lowerthan NGRG group, with statistical significance. But there does not have a statistically significant difference (P>0.05) between the two groups diastolic blood pressure, serumcreatinine, blood urea nitrogen level.(3) Comparison between the two groups of bloodglucose values: fasting blood glucose, postprandial1hour,2-hour postprandial blood glucoselevels of GDM group were significantly higher than NGRG group, and there are significantdifferences with significant difference (P <0.05).3hours postprandial blood glucose levelswere significantly lower than NGRG GDM group with a significant difference (P <0.05).(4)Analysis of serum lipid profile between the two groups:28weeks of gestation and42dayspostpartum were monitored lipid metabolism: gestational diabetes group triglycerides,cholesterol, low-density lipoprotein, apolipoprotein-A were significantly higher than normalpregnancy, and there are significant differences with a statistically significant (P <0.05).High-density lipoprotein levels of gestational diabetes group were significantly lower thannormal pregnancy group with a significant statistical difference (P<0.05).(5) Lipidmetabolism related factors: maternal weight gain during pregnancy status, body mass indexbasis, one hour postprandial plasma glucose may be elevated cholesterol and triglyceridelevels, and2-hour postprandial blood glucose also elevated plasma cholesterol.Conclusion1. Pregnant women with gestational diabetes express higher fastingglucose,1hour and2hours postprandial hyperglycemia and lower three hours postprandialhyperglycemia, so three hours postprandial blood glucose should be monitored to preventpregnancy hypoglycemia.2. Pregnant women with gestational diabetes express highertriglycerides, cholesterol, low-density lipoprotein, apolipoprotein-A increases and lower HDLlevels, even still difficult to recover after production.Besides, elevated blood lipid levels arerelated to maternal underlying index and ponderal growth during pregnancy.3. Pregnancymonitoring of blood glucose, blood lipids, blood pressure and other indicators is particularlyimportant during pregnancy and adjust the diet to improve their living habits, proper exercise,etc. can be effective in reducing the incidence of adverse outcomes of pregnancy.