Impact Of Resting Heart Rate On New-onset Diabetes In Population Without Hypertension

Objective To investigate the impact of resting heart rate (RHR) on new-onset diabetes(NOD) in population without hypertension.Methods This prospective cohort study was performed in2006and2007and screened101,510participants. All subjects were employees of the Kailuan Group, a state-run coalmining company. The observation cohort included48,926subjects with normal fastingblood glucose (FBG)＜7.0mmol/L, no history of diabetes, complete FBG and RHRexamination data, systolic blood pressure＜140mmHg(1mmHg=0.133kPa), diastolicblood pressure＜90mmHg, no history of hypertension, and no use of hypoglycemicagents or antihypertensive drugs. We excluded participants without a health examination in2008～2009or2010～2011and those with incomplete examination data. A total of29,910participants were included in the final analysis. The observation population was dividedinto four groups according to RHR data collected during2006～2007health examinations:quartile1(RHR＜63beats/min); quartile2(63beats/min≤RHR＜70beats/min); quartile3(70beats/min≤RHR＜75beats/min); quartile4(RHR≥75beats/min). The relationshipbetween RHR and NOD was estimated using Cox proportional hazard analysis.Results1The incidences of NOD/1000person-years for the above quartiles of RHRwere11.22,13.58,13.96, and17.55, respectively in the total observational population; thecorresponding incidences were12.17,15.20,16.08,20.44, and8.29,9.38,8.86, and9.60inmen and women, respectively.2Compared with quartile1, Cox proportional hazardregression analysis showed that the other three RHR groups had an increased risk of NODafter adjusting for age, gender, systolic blood pressure, diastolic blood pressure, and otherrisk factors. The hazard ratio values for these groups were1.20(95%CI：1.04～1.40, P＜0.05),1.25(95%CI：1.07～1.45, P＜0.01) and1.58(95%CI：1.36～1.82, P＜0.01),respectively. Furthermore, after adjusted the FBG, risk of NOD was significantly higher inquartile2(HR=1.21,95%CI：1.04～1.40, P＜0.01) and quartile4(HR=1.22,95%CI：1.06～1.41, P＜0.01compared that in quartile1.3After adjusting for the factors listedabove, the influence of RHR on NOD was not significant in women(P＞0.05), but therewas still an increased risk of NOD in men compared with quartile1with hazard ratiovalues of1.21(95%CI：1.02～1.43, P＜0.05), and1.27(95%CI：1.09～1.49, P＜0.01)for quartile2and quartile4, respectively. Conclusion1Higher RHR is linked with higher risk of NOD in population withouthypertension.2The influence of RHR on NOD was significant in men, but not in women.