Change And Significance Of Inflammatory Markers In Blood And Lavage Fluid From Children With Mycoplasma Pneumonia

Objectives1Investigate the levels change and clinical significance of white blood cell,erythrocyte sedimentation rate, C-reactive protein and Interleukin-6, Interleukin-10cytokines in bronchoalveolar lavage fluid from children with refractory mycoplasmapneumoniae pneumonia.2Evaluate the application value of fiber bronchoscopy andbronchoalveolar lavage in children with refractory mycoplasma pneumoniae pneumonia.Methods1Select97cases of children diagnosed with refractory mycoplasmapneumoniae pneumonia and underwent bronchoscopy and bronchoalveolar lavage for thestudy in Tangshan City, MCH Pediatric Respiratory, as the experimental group; select thesame period30cases of children with bronchial foreign bodies hospitalized in ENThospital as the control group1; select the same period30cases of children diagnosedchildren with refractory mycoplasma pneumoniae pneumonia did not receivebronchoscopy and bronchoalveolar lavage in Respiratory, as the control group2，andselect the same period100cases of children diagnosed children with mycoplasmapneumoniae pneumonia in Tangshan City, MCH Pediatric Respiratory, as the controlgroup3.2All the children in the experimental group and the control group1performedelective bronchoscopy performed fibers and alveolar lavage, and use of double-antibodysandwich ABC-Enzyme-linked immunosorbent assay method to detect the levels ofinterleukin-6, interleukin-10in bronchoalveolar lavage; the experimental group and thecontrol group3were admitted to hospital the same day (or the next morning fasting)blood, blood were blood WBC, ESR, CRP; children in the experimental group and thecontrol group2while blood detection of Mycoplasma pneumoniae antibodies, whichMycoplasma pneumoniae antibodies were detected by gelatin particle agglutination test;and children in the experimental group bronchoscopy treatment after one week, accordingto the temperature, cough and lung imaging situation changed markedly points, valid,invalid as postoperative clinical critreria, and the control group2were compared withconventional therapy treatment efficacy.Results1Interleukin-6, interleukin-10levels of the experimental group inbronchoalveolar lavage fluid higher than the control group1, the difference wasstatistically significant (P<0.05).2Blood white blood cell, erythrocyte sedimentation rate, and C-reactive protein levels of the experimental group were higher than the controlgroup3, the difference was statistically significant (P<0.05).3Children in theexperimental group, while the conventional treatment after bronchoscopy andbronchoalveolar lavage, the average time of heat back was the4.48days afterhospitalized, the average time of cough reduce was the5.54days after hospitalized, andthere are65cases of the pulmonary lesions most fundamental absorption in the review ofCT lung after one week, determine the efficacy of the total effective rate was98.1%; thecontrol group2with a single course of treatment with conventional therapy, the averagetime of heat back was the9.33days after hospitalized, the average time of cough reducewas the10.40days after hospitalized, and there are13cases of the pulmonary lesionsmost fundamental absorption in the review of CT lung after one week, determine theefficacy of total effective rate was76.7%, the experimental group and the control group2comparison of efficacy, the difference was statistically significant (P <0.05).Conclusions1Interleukin-6and interleukin-10cytokine levels of bronchoalveolar lavagefluid in children with refractory mycoplasma pneumoniae pneumonia was significantlyincreased, suggesting that its cellular immune function disorder caused by infection playsa role, has some significance for immunomodulatory therapy.2Blood white blood cell,erythrocyte sedimentation rate, C-reactive protein levels increased in varying degrees inchildren with refractory mycoplasma pneumoniae pneumonia, these inflammatorymarkers elevated to a certain extent reflect the severity of the disease.3Bronchoscopyand bronchoalveolar lavage is an important means of treating refractory mycoplasmapneumoniae pneumonia, which can significantly improve the cure rate of refractorymycoplasma pneumonia.