Level Of TXB2 In Bronchoalveolar Lavage Fluid In Children With Mycoplasma Pneumoniae Pneumonia And Its Relationship

Mycoplasma pneumoniae pneumonia?MPP?accounted for about 20%of children,in densely populated up to 50%.Perennial can occur,the popular cycle of4-6 years,mainly through the respiratory tract.In recent years,the incidence of refractory and severe mycoplasma pneumoniae pneumonia increased significantly,seriously affecting the quality of life of children,and even life-threatening.In clinical practice,we found that some of the children who with MPP,under fibrobronchoscopy the airway mucus showing a high secretion state,and some may even form a large number of airway mucus plug,leading to gas road narrow or blocked,eventually leading to serious sequelae.TXB2 is a metabolite of arachidonic acid and is an important inflammatory mediator.It is involved in a variety of inflammatory and immune responses.In patients with COPD,TXB2 can promote increased vascular permeability,leading to airway microvascular leakage,resulting in increased airway mucus^[6].The blockade of TXB2 receptors can reduce the excessive production of airway mucus caused by smoking^[7].At present,researches on TXB2 at home and abroad mostly focus on thrombosis,COPD and so on.However,there are few studies on mucus thrombosis caused by MP infection in children.Therefore,the relationship between TXB2 and MPP airway mucus plugs is discussed in this paper in order to find out.Effectively predicts the biological indicators of airway mucus plugs caused by MP infection and performs more effective targeted therapies.Objective1.To understand whether there is any difference in the duration of disease,age,and various inflammatory indicators in children with MPP who have airway mucus plugs,and to provide basis for judging the severity of the disease in children with the characteristics of airway mucous plug changes under the tracheoscope,and assess the condition;2.The levels of TXB2 in the bronchochoallavone lavage fluid?BALF?were measured in all groups,and the relationship between TXB2 level and airway mucus plugs and the relationship between TXB2 levels and RMPP/SMPP in children with MPP were investigated.Methods1.Collected in December 2016 to August 2017 diagnosed with MPP need bronchoscopy and alveolar lavage in hospitalized children in 50 cases?24 cases of mucus suppository,non-viscose plug group of 26 cases?;and the final line of bronchoscopy 25 cases of children diagnosed with airway foreign body as the control group.BALF and blood samples were left in each group,to detect TXB2 levels,MP antibodies,etc.At the same time access to all subjects of the medical records,and analysis.All data are analyzed using SPSS21.0 statistical software,measurement data are expressed with data.The t-test was used to compare the two groups.Pearson test was used to analyze the correlation between the two variables.When?=0.05 was used as the test level,P<0.05 was considered statistically significant;2.The study met the criteria of the hospital ethics committee and obtained the informed consent of the guardian of the child through written approval of the Ethics Committee and signed a written informed consent form.Results1.A total of 50 children with MPP were enrolled in the study?24 in the mucus plug group and 26 in the non-mucinous plug group?.With the appearance of mucus plugs in the airway,the duration of the MPP children was prolonged,and the age of onset was relatively large.The differences were statistically significant.?P<0.05?.See Table 3.2;2.The level of TXB2 in MPP group was higher than that in airway foreign body group,and the difference was statistically significant?P<0.05?.See Table 3.3;The level of TXB2 in mucus plug group was higher than that of non mucus plug,and the difference was also statistically significant?P<0.05?.See Table 3.4;the levels of inflammatory indexes in peripheral blood of MPP group were significantly different from those in non mucus group?P<0.05?.See Table 3.4;And the level of TXB2 in the MPP mucus group was positively correlated with various inflammatory parameters.See Figure 1.Conclusions1.Children with MPP combined with airway mucothrombus under the bronchoscope during the acute phase had relatively longer duration and relatively older age than those without airway mucothrombus;2.The levels of various inflammatory markers?WBC,N%,PLT,CRP,LDH?in peripheral blood of children with MPP mucus plug group were different from those in non-mucosal plug group,indicating that the heavier the MPP,the stronger the inflammatory reaction in the body,and the higher the index of inflammation;3.The level of TXB2 may affect the inflammatory response process in MPP children,resulting in the formation of airway mucus plugs,leading to refractory mycoplasma pneumonia pneumonia or severe Mycoplasma pneumonia.