Effect Of Intraoperative Amino Acid Infusion On Postoperative Liver And Renal Function In Elderly Patients Undergoing Gastrointestinal Surgery

Objective:To investigate the effect of amino acid infusion on postoperative liver and renal function in elderly patients undergoing gastrointestinal surgery.Method:Forty ASA Ⅰ or1Ⅰ patients(33male,7female) aged65-75yrs undergoing elective gastrointestinal cancer operation under epidural block combined with general anesthesia were randomly divided into2groups (n=20each). group Ⅰ received intravenous infusion of mixed amino acids at a rate of2ml·kg-1·h-1from induction of anesthesia to the end of operation (AA group); group Ⅱ received infusion of equal volume of normal saline (NS group). Snuff temperature was monitored for induction of anesthesia immediately, after90min and closed abdominal. Renal and hepatic function was performed regularly before operation and on the1st and7rd postoperative dayResults:There was no significant differences in hepatic and renal function between the two groups. there were significant increases in both TBIL, DBIL,ALT, AST (P<0.05) after operation, whereas TP, ALB, BUN, Scr and UA decreased significantly (P <0.05), hepatic and renal function index were within the normal range in the two groups.groups. No patient developed renal or hepatic failure.Conclusion:Intraoperative amino acid infusion has no significant effects on the renal and hepatic function in elderly patients undergoing gastrointestinal surgery.