| Objective:To evaluate the value of PTH in predicting hypocalcemia at different times after thyroidectomy.Methods:The literatures in CBMdisc, WanfangData, CNKI, VIP in Chinese,and OVID,PUBMED,EMBASE,and MEDLINE in English were searched. Hand searches and additional searches were also conducted. The studies of predicting hypocalcemia after thyroidectomy by detecting postoperative PTH at different times were selected, and the quality and tested the heterogeneity of included articles were assessed. Then the proper effect model to calculate pooled weighted sensitivity (SEN), specificity (SPE), positive likelihood ratio (+LR), negative likelihood ratio (-LR) were selected. The Summary Receiver Operating Characteristic (SROC) curve was performed and the area under the curve (AUC) was computed.Results:Twenty-three articles entered this Systematic review,21English articles and2Chinese articles. Fifteen of23articles was designed to be prospective cohort study (PC) and8of23articles was retrospective study (Retro). These articles was divided into two groups. Group1was the studies of detecting postoperative PTH in1hour, which included2012cases (494of them occurred hypocalcemia). Group2was the studies of detecting postoperative PTH between4hours to12hours, which included693cases (266of them occurred hypocalcemia). We selected the appropriate effect model to calculate2groups’ pooled weighted the area under the curve [0.9703(0.9503-0.9902),0.9525(0.9311-0.9739)]. At last, we compared two groups, it presented that predict power of Group1was better than Group2.Conclusion:Detecting postoperative PTH is serviceable process to predicting hypocalcemia after thyroidectomy. |
