| 1.Objective:To explore the effect of dexmedetomidine intranasal drip on infanticide in anaesthesia resuscitation room and its effects on postoperative restlessness and adverse reactions.2.Methods:This study was approved by the Shenzhen Luohu hospital medical ethics committee.The informed consent were signed by families,300 cases of children who were treated with the anesthesia recovery room pediatric anesthesia surgery as the research object between Jan.2016 and Sept.2017 were chosen,and they were randomly divided into three groups according to the child’s admission order,with 100 cases each group.For the first and second groups,the dosages of dexmedetomidine were 0.5 ug/kg and 1 ug/kg,and 0.4 ml saline was used in the third group for nasal drops.Children in the three groups were accompanied and monitored by specialized anesthesiologists and their own parents before the start of surgery after completion of medication.After waiting for 30 min in the waiting area,the parents accompanied the children to the anesthesia induction room for induction.All children were given medicine to kilogram weight of fentanyl,midazolam,propofol,and cis-atracurium for induction of anesthesia,intraoperative sevoflurane inhalation,intermittent intravenous fentanyl and cis-atracurium maintained bispectral index(BIS)between 40 to 60,and assessment of sevoflurane inhalation was stopped 10 minutes before completion of surgery.An anesthesiologist who did not know the study design was also assigned to observe and record the data of the children.After the operation,the children were sent to the anesthesia resuscitation room,and the HR and systolic blood pressure were recorded at the end of the operation and 5 min,15 min,and 30 min after entering the resuscitation room,respectively.Preoperative sedation satisfaction,waking time and the agitation of 5 min,30 min and 60 min at different moments after awakening were also recorded.The incidence of adverse reactions in the three groups was calculated.3.ResultsComparing the hemodynamics of the three groups of children,the vital signs were stable,and the fluctuation range did not exceed 10%.At the end of the surgery,the HR of the second group was the lowest,and the HR of the third group was the highest.After entering the anesthesia resuscitation room,the HR of the first group and the second group at 5 min,15 min and 30 min was lower than that of the third group.In children,the HR reduction in the second group was the fastest and the lowest,the difference was comparable(P < 0.05);at the end of the surgery,the systolic blood pressure was the lowest in the second group,and the systolic blood pressure was the highest in the third group.After entering the anesthetic resuscitation room,the systolic blood pressure of the first and second groups was lower than that of the third group of children at 5 min,15 min and 30 min,in which the second group had the fastest reduction in HR,and the differences were comparable(P < 0.05).The preoperative composure of children in the first,second,and third groups was 16.0%,51.0% and 10.0%,respectively,and the first and second groups’ recovery time were significantly lower than that of the third group.The three groups’ agitation scores of 60 min after resuscitation were significantly lower than those of 5 min after resuscitation,and the second group of agitation scores after 60 min of resuscitation was significantly lower than that of the other two groups(P < 0.05).No adverse reactions such as respiratory depression,vomiting,throat and bradycardia were observed in the first and second groups.Only a small number of children in the third group had adverse reactions,and the difference was comparable(P < 0.05).4.ConclusionThe dexmedetomidine intranasal drip is safe and effective for general anesthesia on children.The use of a reasonable dose of dexmedetomidine is very effective for increasing the satisfaction of preoperative sedation,reducing the recovery time,improving postoperative restlessness scoreand and reducing the incidence of adverse effects. |
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