Study On The Effect Of Basic Fibroblast Growth Factor (bFGF) On The Periodontal Healing Of Tooth Replantation

ObjectiveTo establish an experimental animal model of anterior teeth replantation,basic fibroblast growth factor implantation on periodontal ligament remodeling.Methods6healthy dogs (24canine teeth) were randomly divided into4groups, theexperimental animal model of anterior teeth replantation, First groups ofanimal teeth replantation of teeth and the left alveolar do not handle asexperimental group.Second groups of animal teeth on the left side of toothreplantation for root canal treatment, alveolar fossa not treated as theexperimental group. Third groups of animal teeth replanted teeth left untreated,alveolar fossa coated bFGF as the experimental group. Fourth groups ofanimal teeth on the left side of tooth replantation for root canal treatment,alveolar fossa coated bFGF as the experimental group. Frequently take X-ray,observation of teeth and periodontal conditions. After12weeks of histologicalobservation, respectively in normal periodontal index of each tooth calculation(percentage of normal periodontal sites) and3absorption index (3absorptionsite percentage), The results of statistical analysis.ResultsThe second group, fourth groups of two groups of various absorptionindex and normal periodontal index was not significantly different, with themost surface absorption, bone absorption is rare, and the normal periodontalmembrane ratio close to1/3; third groups of replacement resorption rate than the first group was significantly lower than the first group, significantly higherrates of normal periodontal membrane.ConclusionsFibroblast growth factor can reduce the occurrence of non root canaltreatment alternative absorption of replanted teeth in the local application ofbasic conditions, and can promote the healing of periodontal tissue of normal.