A Review Of Clinical Characteristics Of97Patients With Sheehan’s Syndrome

Objective:To describe the clinical and hormonal characteristics of patients with Sheehan syndrome. Methods:Patients with Sheehan syndrome(n=97), who were diagnosed and treated in our hospital were included. Medical history hormones related with the anterior pituitary gland were documented and retrospectively analyzed Results:Ninety seven patients with Sheehan syndrome were identified. The age for initial diagnosis was43.7±12.4years. The average periods from the previous obstetric events to diagnosis of Sheehan syndrome was9.1±9.5years. History of obstetric hemorrhage was reported in96patients(99.0%). Common symptoms included amenorrhea in80patients(82.5%), agalactia in72patients(74.2%), and loss of axillary or pubic hair in83patients (85.6%).Laboratory tests showed that0of25patients (0.0%) had GH deficiency,77of83patients (92.8%) had LH deficiency,73of83patients (88.0%) had FSH deficiency,62of82patients (75.6%) had E2deficiency,47of82patients (57.3%) had PRL deficiency,77of93patients (82.8%) had TSH deficiency,70of87patients (80.5%) had TT3deficiency,72of87patients (82.8%) had TT4deficiency,19of37(51.4%) patients had ACTH deficiency,49of64(76.6%) patients had cortisol deficiency. Conclusion:Diagnosis of Sheehan syndrome is delayed in most of the patients. Appropriate and multiple hormonal replacement therapy may completely alleviate the symptoms.