Relationship BetweenSOCS-3Gene Polymorphism And Abnormal Glucose Metabolism In The Xinjiang Uygur Population

Objective:To investigate the relationship between SOCS3gene polymorphism and abnormal glucose metabolism in Xinjiang Uygur population. Methods:According to different plasma glucose levels,1232individual in xinjiang hetian area were divided into3groups that is451patients with pre-diabetes(PD group),252patients with type2diabetes mellitus (T2DM group) and529healthy people as normal controls (NC group). Based on HapMap and NCBI databases we selected the polymorphismrs rsl2953258,rs4969168, rs9914220as tagging SNP (htSNP) sufficiently covering the genetic variation of the whole gene. We therefore examined the association between rs12953258, rs4949168and rs914220within SOCS3and abnormal glucose metabolism in the Xinjiang Uygur population in three independent study populations; The genotype and allele frequencies and relative clinic data were compared among groups. Results:The T2DM study with451individuals showed the thomozygosity for the C allele of rs12953258polymorphism of SOCS3was associated with increased diabetes risk (OR=1.756,95%CI (1.168,2.640)). In addition, association between rs4949168,rs914220and abnormal glucose metabolism in the Xinjiang Uygur population was not found. Age,total cholesterol (CHOL) and BMI were risk factors of DM development, total cholesterol (CHOL) and low high-density lipoprotein (HDL-C) was risk factors of PD development in Uygur people. Conclusions: The C allele of rs12953258polymorphism of SOCS3gene may be an independent risk factor for abnormal glucose metabolism in Xinjiang Uygur population.