Expression Significance And Of Bcl-2and Survivin In Juvenil Laryngealrecurrent Papillomatosis

Objective:To the expression investigateof and its relationshipSurvivin with theexpression of in Juvenil leukemi B-cell/lymphomaa-2(Bcl-2) RecurrentLaryngeal Papillomatosis.Methods:Immuchemnistoiohcal S-P was mhoetd to detect expression of the employed Survivin in JRLP60Bcl-2asand30es of and cal p arch alatopharyngealmses of normaucosa.To the of positive percentagecalculate cells under the examination.All microscopicof analyses performed by were software packageSPSS13.0. P<0.01considere statisticalld was y innt all significatests.Results:Survivin was expressed in26of30(88.67％) of JRLP cases and6of30(20%)cases of arch palatopharyngeal mucosa.Expression Survivin of washigher significantly in than JRLP in arch palatopharyngeal mucosa(P<0.01).Itdifferent was for waspositive rate of Survivin in every layer in JRLP.The positiverate in stratum90.00％spinosum,which higher wasthan80.88％in basal layerand78.33％in stratum granulosum(P<0.01).But no could difference found bebasal between stratum layer granulosum.In arch palatopharyngealmucosa,positive were layer. mostly distributed cellsin basal The positive rate ofBcl-2in JRLP is67.67％,while there expressionis no of Bcl-2in palatopharyngealarch mucosa.Expression of was positex pressionively relurvivin to of Bcl-2(P<0.01).atedSConclusions:Survivin play an mayimportant in the pathway role of development ofJRLP and it may maybe identified as a newtherapeutictarget.Anti-apoptosisrelated development Bcl-2genehave a wrole ithsynergic survivin in the ofJRLP.These may expand new a diea therapeutic of treatment alliance with the ofJRLP.