Plasma Ghrelin Concentration In Patients With Acute Coronary Syndrome Correlates With Coronary Lesion’s Degree And Recent Prognosis

Aims:1.To explore the significance of plasma Ghrelin levels in patients with AcuteCoronary Syndrome in evaluating coronary lesion’s degree.2. To discuss the value of plasma Ghrelin level on recent prognosis in AcuteCoronarySyndrome.Methods:The research objects included123inpatients who be hospitalized because ofchest pain or chest discomfort and underwent diagnostic coronary angiography fromFebruary2013to September2013in Department of Cardiovascular Diseases of thesecond affiliated hospital university of south china.They were divided into non-CHDcontrol group with30patients and Stable angina pectoris(SAP) group with32patientsand Acute Coronary Syndrome(ACS) group with61patients.The Acute CoronarySyndrome group was also divided into two groups,including39cases of unstableangina pectoris(UAP) and22cases of acute myocardial infarction(AMI). plasmaGhrelin levels was measured by Enzyme-linked immunosorbent assay.The number oflesion vessel was calculated by international general Judkins method and GensiniScore estimated coronary lesion’s degree according to the results of CAG.All theadverse cardiac events occurring during hospital stay and within2months afterdischarge including cardiac death,arrhythmia, intractable angina,heartfailure,recurrent myocardial infrarction.Results:1. plasma Ghrelin levels was significantly lower in CHD group than non-CHDgroup(P<0.05). plasma Ghrelin levels in AMI group was significantly lower than UAPgroup(P<0.05). plasma Ghrelin levels in UAP group was significantly lower than SAP group(P<0.05).2. Plasma Ghrelin levels gradually decreases with the increase of coronary arterylesion counts, The level of plasma Ghrelin was slightly lower in two lesion vesselsgroup than one lesion vessel group,But there was no statistical significance betweenthem（P>0.05). The level of plasma Ghrelin was significantly lower in three lesionvessels group than two lesion vessels group and one lesion vessel group(P<0.05). Splasma Ghrelin levels was negative correlated with Gensini score.（r=﹣0.722,P<0.05）.3. Compared to no-cardiovascular events group, the cardiovascular events grouphad lower levels of Plasma Ghrelin,there was statistical significance betweenthem(P<0.05). Correlation analysis showed that the plasma Ghrelin levels wassignificantly negative correlated with heart failure patients (r=-0.487, P <0.487),severe arrhythmia (r=-0.283, P <0.05),and intractable angina pectoralis (r=-0.353,P <0.05) during hospitalization and discharge two months. Plasma Ghrelin levelswere also significantly negative correlated with the overall incidence ofcardiovascular events (r=-0.564, P <0.05). Logistic regression analysis showed thatplasma Ghrelin levels are independent protection factors for prognosis in patients withacute coronary syndromes（OR=.0.162,P=0.031）.Conclusions:1. Plasma Ghrelin levels may be useful for risk stratification in coronary arterydisease.2. Plasma Ghrelin levels may be reflect the severity of coronary lesion in patientswith ACS.3. The plasma Ghrelin levels may have predictive value for the recent prognosisof ACS.