Intestinal Acid Binding Protein Changes And Clinic Significance In Strangulated Intestinal Obstruction

Objective: Through the establishment of rabbit simple andstrangulated intestinal obstruction model, to observe the blood intestinalfatty acid binding protein (IFABP) changes and trends, and then exploredthe meaning and value of IFABP index in the diagnosis and treatment ofstrangulated intestinal obstruction.Methods:65healthy New Zealand rabbits were selected, randomlydivided into sham operation group with10, simple intestinal obstructionGroup15, strangulated intestinal obstruction group was40, and accordingto the different of strangulation bowel length divided into eight groups,each group of five rabbits. Respectively with the method of bowel cerclageand strangulated hernia method to establish appropriate animal models, andin every hour after extracting arterial blood, detecting the concentration ofIFABP.Results: The average concentration of sham operation group IFABP is22.01ng/ml, the average concentration of IFABP is237.61ng/ml simple group, and the two groups had no time variation trend. Strangulation groupIFABP minimum is160.80mg/ml, maximum2003.86mg/ml, and over time(8hours) increased with the extension of trend, and there is a directproportion relationship between the length and strangulation. Theconcentration of IFABP between the three groups were significantdifferentce (P <0.05).Conclusions: IFABP may be useful marker in the early diagnosis ofstrangulated intestinal obstruction, and had very usefull in the differentialdiagnosis and the choice of operation time and manner,but still needs moreclinical trials to prove.