Evaluation Of Ischemic Bowel Disease With MSCTA Combined With Serum I-FABP And D-LAC

ObjectiveTo investigate the serum I-FABP and D-LAC levels in patients with ischemic bowel disease(ICBD)and non-ischemic bowel disease(NICBD)and to analyze imaging features of MSCTA to investigate the correlation between serum I-FABP、D-LAC levels with imaging signs,compare the diagnostic efficiency of ICBD.MethodsThe general clinical data of the two groups of patients were analyzed and the difference of general clinical data between the two groups of patients was explored.The distribution of serum I-FABP and D-LAC levels in the two groups of patients were measured and those data were compared.The diagnostic efficacies of I-FABP,D-LAC and imaging scores in the diagnosis of ischemic bowel disease were compared.The correlation between serum I-FABP and D-LAC levels and imaging scores were analyzed.ResultsThe age of ICBD group was higher than that of NICBD group(P<0.05).There were no significant difference in gender,basic disease,body temperature,WBC and D-dimer between the two groups(P>0.05).The median serum I-FABP and D-LAC levels in the ICBD group were higher than those in the NICBD group and there were significant difference(P<0.05).The critical value of serum I-FABP and D-LAC in diagnosis of ischemic bowel disease were 477.91pg/ml,10.56 pg/ml relatively.The area under the ROC curve ofserum I-FABP,D-LAC and imaging scores were 0.92,0.82 and 0.79 respectively.The area under the ROC curve of serum I-FABP combined with serum D-LAC was 0.92,the area under the ROC curve of serum I-FABP combined with imaging scores was 0.92,the area under the ROC curve of serum D-LAC combined with imaging scores was 0.89,the area under the ROC curve of serum I-FABP combined with LAC,imaging scores was 0.93 and there were no significant differences in the combined diagnosis.There was a correlation between image scores and I-FABP concentration measurements(r_s=0.637,P=0.001).Conclusions(1)The age of ICBD group is older than that of NICBD group.(2)The serum I-FABP and D-LAC levels in patients with ICBD were significantly higher than those in NICBD.(3)The diagnostic efficacy of I-FABP,D-LAC and imaging scores were clinically significant and decreased in turn.(4)Although the area under the combined diagnostic curve of serum IFABP,D-LAC,and imaging scores was larger than that of the single image score,there was no significant differences.(5)There is a certain correlation between serum I-FABP levels and image scores.