Analysis Of Surgical Treatment And Prognosis In Retroperitoneal Soft Tissue Sarcomas

Objective:To assess clinical, pathological and treatment-related factors affecting prognosis in patients with retroperitoneal soft tissue sarcomas.Methods:Between June12007and December312012, the clinical data of307patients who underwent surgical tretment for retroperitoneal soft tissue sarcomas and released from Zhongshan hospital of Fudan university were reviewed. Exclusive criteria:patients who is not willing to accept follow-up; who died at perioperative period;who died of other diseases or other reasons during follow-up. The data including clinical characteristics, pathological data operative procedure and prognosis were studied. Kaplan-Meier estimations and Cox regression analyses were performed. Statistical analysis was performed using the IBM SPSS Statistics (version21.0, Chicago, IL, USA). P values<0.05were considered to be significant.Results:Median follow-up was28months (interquartile [IQ] range,1-66months). Complete macroscopic resection was achieved in257cases(83.7%). At1,3,5years, overall survival was81.7%,72.0%,59.9%, respectively; At1、3、5years, progression free survival was66.7%,43.4%,13.3%; local recurrence crude cumulative incidences were45.5%%. Multivariate analysis showed that histological subtype, histological grade, AJCC staging and surgical approach can be regarded as independent prognostic factors of RSTS overall survival; histologic subtype, histological grade, primary or recurrent, surgical margins can be regarded as independent prognostic factors of RSTS progression free survival.Conclusions:The optimal treatment of patients with primary retroperitoneal sarcoma should be based on radical surgery, with en bloc organ resection if necessary, to minimize the risk of positive margins.