Pregnancy Outcomes After Cervical Conisation Of Cervical Intraepithelial Neoplasia:A Meta-analysis

Objective:Explore cervical intraepithelial neoplasia patients with cervical conization on pregnancy outcome, childbirth outcomes. Methods:We searched Cochrane Library, PubMed, SCI and Wanfang, CNKI, CBM and other databases and supplemented by hand searching of relevant journals, retrieval time until March2013. Screened by two independent investigators literature, data extraction and methodological quality assessment, using RevMan5.1.7software for Meta-analysis. Results:Were included in the case-11controlled trials, Including721cases of cases and5565controls.Meta-analysis results showed that:with and without cervical conization compared to the normal population, cervical conization surgery for the treatment of young fertility requirements cervical intraepithelial neoplasia cervical laceration during delivery the incidence was not statistically significant [OR=2.15,95%CI(0.51,9.09), P=0.30]; Pregnancy rate was not statistically significant [OR=1.02,95%CI (0.59,1.76), P=0.94]; Mode of delivery (cesarean section or vaginal delivery) no statistically significant [OR=1.04,95%CI (0.86,1.27), P=0.06]; The incidence of abortion was not statistically significant [OR=1.34,95%CI (0.81,2.23), P=0.26]. However, rates of preterm birth [OR=2.16,95%CI (1.56,2.99), P<0.00001], the incidence of premature rupture of membranes [OR=2.82,95%CI (1.70,4.67), P<0.00001], newborn children the incidence of low birth weight children [OR=2.62,95%CI (1.62,4.24), P<0.00001], etc. There are statistically significant. Conclusion:No cervical conization compared to the normal population, cervical conization surgery on postoperative pregnancy, mode of delivery, cervical laceration and the abortion rate has no effect, but will increase after premature rupture of membranes and low birth the incidence of weight children.