The Clinical Research Of Effection Of An-zi Mixture In The Threatened Abortion And The Serum Concentrations Of TNF-α

Objective:To explore the clinical efficacy and mechanism of An-zi mixture in the treatment of the deficiency of the spleen and kidney, complicated with blood heat and stasis of the threatened abortion.Methods:60patients were selected and randomly devided into treatment group and control group. Treatment group was given An-zi mixture orally, and intramuscular injection of progesterone injection and/or human chorionic gonadotropin; The control group was treated with intramuscular injection of progesterone injection and/or human chorionic gonadotropin. Setting five weeks as a course of treatment.Symptoms,signs,the levels of E2, P, β-HCG, TNF-a of the blood Plasma and the B ultrasonic of each group were observed before and after treatment.Results:①Syndrome integralCompare the symptom total score before and after treatment in two groups, numerical significantly less than before treatment (P<0.05). Comparison between the two groups, two groups after the treatment, the total symptom score was statistically significant (P<0.05), indicating that the treatment group in improving symptoms was superior to the control group (P <0.05).②Pregnancy hormonesThe two groups of serum E2, P,β-HCG levels were higher than those before treatment. Suggest that combination therapy group is better than control group, and An-zi mixture can help increased serum pregnancy hormone levels, in favor of tocolysis.③. TNF-α levelsAfter treatment, two groups of TNF-α levels were lower than that before treatment (therapy group:P<0.05; control group:P<0.05); comparison between groups, the difference has statistical significance (P<0.05), the treatment group was better than the control group.④B-ultrasonic mornitoing pregnant burse After treatment, there was statistically significant between two groups(P<0.05). There were27cases embryo formation in the treatment group and23cases in the control group. The success rate of the treatment group (90.00%) was significantly higher than the control group (76.67%). It showed that An-zi mixture can promote the growth, development of gestational sac and improve the success rate of miscarriage.⑤The comprehensive curative effectThe total efficiency of the treatment group was90.00%, the control group was76.67%. the difference was statistically significant(P<0.05). The treatment group was significantly higher than that of the control group.Conclusion:An-zi mixture clinical definite curative effect in treating the deficiency of the spleen and kidney, complicated with blood heat and stasis of the early threatened abortion. It can improve the clinical symptoms,increase the serum E2, P, β-HCG levels, decerease the serum TNF-a levels, and promote the embryo development.