The Serum Adropin Leverls In Patients With Coronary Artery Disease And Discussion On Its Clinical Significance

ObjectivesOur study was designed to observe the changes of the serum adropin levels in patients with coronary artery disease, and to discuss the prediction of the severity of coronary artery lesion. We analyzed the correlation between adropin concentrations and high sensitivity C reactive protein.MethodsWe recruited74patients in the cardiovascular department of the Second Xiangya Hospital of Central South University from Sep,2013to Feb,2014, who were diagnosed with coronary heart disease(the severity of coronary artery stenosis more than50percentages) by coronary angiography. We classified patients into3groups:single diseased coronary vessel group (24cases), double diseased coronary vessel group (28cases), many diseased coronary vessel group (22cases). We collected22cases certified with no coronary artery disease by coronary angiography as control group. All of the patients’ general clinic data were collected. We used special computer software to calcμlate the coronary Gensini score. According to the Gensini score,3groups were divided: mild stenosis group (<30points) including25cases, moderate stenosis group (30-90points) including20cases and severe stenosis group (>90 points) including29cases. The serum adropin was measured by enzyme linked immunosorbent assay(ELISA).ResultsThe resμlts showed that the serum adropin levels were significantly decreased in the coronary artery disease, comparing with the patients in control group(3.53±1.39ng/ml vs5.48±0.86ng/ml, P<0.05). The serum adropin levels in double diseased coronary vessel group and many diseased coronary vessel group were significantly lower than single diseased coronary vessel group(3.47±1.19ng/ml vs4.56±1.25ng/ml,2.48±0.94ng/ml vs4.56±1.25ng/ml, P<0.05). The serum adropin levels in many diseased coronary vessel group were less than double diseased coronary vessel group(2.48±0.94ng/ml vs3.47±1.19ng/ml, P<0.05). Furthermore, lower serum adropin levels were negatively corelated with coronary Gensini score and high sensitivity C reactive protein.Conclusions(1) Lower serum adropin levels in patients with coronary artery disease comparing with control group and generally concentrations decreased following by increased amounts of coronary lesions. Lower serum adropin was negatively correlated with coronary Gensini score.(2) Lower serum adropin was negatively correlated with high sensitivity C reactive protein. Adropin may protect coronary artery disease against inflammation.