Analysis Of Survival And Prognosis Factors Of In-patients With Pancreatic Cancer

Objective: To understand the survival situation of patients with pancreatic cancerand analyze prognostic factor of pancreatic cancer.Methods: Patients were selected from Henan Cancer Hospital from November2011to February2013，who were diagnosed pancreatic cancer and hospitalized, thepersonal information、 diagnosis and treatment information were collected byquestionnaires. Epidata3.1was applied to setup a database. Survival time wascomputed from the first time to treat. All the cases were followed until February28th2014. SAS9.1was used to statistics and analysis. Prognostic factors were analyzedin Cox regression.Results:1.105in-hospital cases of pancreatic cancer were recruited into the studyduring the period of collecting information. In the105cases of pancreatic cancer, thenumber of male and female were49（46.67%）and56（53.33%）, respectively. Agewas in38-83years old, the average age was59.3±9.2years old. None of the patientslost to follow-up at the deadline for follow up.86cases were complete data,19caseswere censored data.2.Survival rate： The1-year survival rate and2-year survivalrate of105cases with pancreatic cancer were44.1%（95%CI:34.5%-53.4%） and11.32%（95%CI:12.26%-28.8%）, respectively. The median survival time was290days（95%CI：233-423）. The differences of the gender and the education influencethe survival of the cases with pancreatic cancer. The social economic statues hadlittle impact on the survival rate of the pancreatic cancer. The1-year、2-year survivalrate were55.3%、32.6%for the cases with CA19-9≤37u/ml, which had highersurvival rate than those with CA19-9＞37u/ml. CEA≤5ng/ml was a good indicatorfor pancreatic cancer (P=0.002). TNM stage(P=0.002)、treat method (P=0.0005)influenced the survival rate of the patients with pancreatic cancer.3. Prognosisfactors analysis：Univariate factor analysis show that, education background、cholecystitis、stomachache、tumor-marker CA19-9and CEA、TNM、therapies areassociated with the prognosis of pancreatic cancer(P<0.05). After adjusted for possible confounding factors, there was no significant difference betweencholecystitis、stomachache、tumor-marker CA19-9、CEA and pancreatic cancer. Thepatients received operation combined with adjuvant therapy had better prognosisthan those with surgery or adjuvant therapy alone (P<0.05), with statisticalsignificance. Sex、social economic statues、acute-pancreatitis、chronic pancreatitis、BMI、diabetes mellitus、location,tumor size were uncorrelated with prognosis ofpancreatic cancer(P>0.05). Multiple-factor analysis of Cox regression indicate that,CA19-9、TNM and treat-methods were significantly correlated with the prognosis ofpancreatic cancer. TNM is a strong predictor (HR:1.378,95%CI：1.089-1.745，Ptrend=0.0076）; Different treat methods were closely associated with the survival inpatients (Ptrend=0.0013).Conclusion: The survival time of pancreatic cancer is short and the prognosis ispoor. TNM stage、treatment method、tumor-marker CA19-9are related with theprognosis closely. Early diagnosis and active treatment are important to improve thepatients’ quality of life, prolong the survival time.