| ObjectiveClinical Hospital of Zhengzhou City, Dermatology February2010March2013outpatients shingles (Herpes Zoster, HZ) patients in the Western combination therapy situation, summed draw multiple seasons of herpes zoster, predisposing factors, disease location, before and after treatment of the distribution of T cell subsets, combined Chinese and Western medicine and other clinical conditions,in order to improve and perfect combination therapy of Chinese and Western medicine and provide evidence of herpes zoster.MethodsRetrospective application of the method to select136patients meet the criteria,70male patients (age21-55years),66cases of female patients (aged20-45years), with typical skin lesions, clinical manifestations, the degree of pain varies. Any unused antivirals before treatment, while no significant hypogonadism, cachexia and cancer incidence. Lighter and observing the patient’s condition, sicker patients in hospital. The method of treatment according to the patient to take the patients were randomly paired into three groups:Chinese medicine treatment group:Select the liver swelter type45cases, giving Longdan Xiegan decoction oral,topical Xinhuang Tablets crushed; Western medicine treatment groups:the use of anti-viral drugs valacyclovir, pain medications γ-aminobutyric acid (GABA) receptor agonist-pregabalin, the drugs derived neurotrophic coenzyme B12-mecobalamin oral tablets, topical Yallaferon45cases, Western medicine combination therapy group: Select syndromes belong to the liver swelter type, while Western medicine treatment of46cases of application.Three groups were given15days of treatment. Observed three groups of patients prone season, predisposing factors, disease location, distribution of T cell subsets of patients before and after treatment, combined western medicine and other clinical situations, and compared three groups of patients differences in efficacy.ResultsThe study found that the number of patients with herpes zoster outpatient highest in spring and autumn, the number of least for the summer, no significant difference between summer and winter festival. Predisposing factors, and emotional factors, upper respiratory tract infection, fatigue majority. Shingles predilection sites occupied by the body size ratio:45%of chest and back, head and face15%,14%of the waist and abdomen, limbs,14%neck,12%, systemic1%. Three groups of patients, accompanied by their disease,80cases of the more common diseases associated with cholecystitis, hypertension, gastritis, diabetes, fatty liver, coronary heart disease and so on. Associated with other diseases, neuralgia occurs first, prone condition misdiagnosed, most misdiagnosed in pain after the occurrence of localized lesions to error correction. In136cases of patients, the total efficiency, T cell subsets recovery, skin lesions subsided, time and other aspects of pain, the treatment group was significantly better than the medicine group, treatment group.Chinese and Western medicine treatment of herpes zoster combined group total efficiency is96%, significantly higher than87%of the treatment group using traditional Chinese medicine, Western medicine treatment group was91%. Chinese and Western medicine combined group before treatment CD3(%), CD4(%), CD8(%),CD4/CD8were54.45±7.33,30.76±7.96,30.64±7.41,1.00±0.68,63.77±7.43, respectively after treatment,38.06±8.83,25.23±6.21,1.51±0.79, compared before and after treatment, Chinese medicine and Western medicine more significant changes. Three groups of patients in the skin lesions subsided time, TCM treatment group averaged6.12±4.97, Western medicine treatment group averaged6.56±5.07, Chinese medicine treatment group7.13±4.12. Three groups of patients with persistent pain, time difference, in Western medicine treatment group averaged17.36±5.93, Western medicine treatment group averaged18.52±6.95, Chinese medicine treatment group19.12±7.17.ConclusionThe use of immune regulation, internal medicine, painkillers, antiviral, glucoco-rticoids, external use, such as neurotrophic integrated Chinese and Western medicine combination therapy of herpes zoster, the advantages of having a good effect, combined Chinese and Western medicine treatment group was significantly Chinese medicine and Western medicine treatment group than the treatment group. Western methods of combination therapy will become a major treatment in clinical treatment of herpes zoster, in order to reduce complications and improve quality of life for patients. |
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