The Clinical Study On The Knee Osteoarthritis Of Yang Deficiency And Congealing Cold With Warming Yang And Activating Blood Circulation

Osteoarthritis, also known as knee osteoarthritis, knee or proliferative arthritis, main pathological features is the joint degeneration, cartilage ossification, and marginal spurs generated Knee joint degenerative diseases. According to the main symptoms of their disease, belong to the motherland medicine "arthralgia","bone rheumatism" etc... For the treatment of this disease, TCM inner treatment has a long history and the curative effect is remarkable. The Chinese medicine decoction taken orally is one of the major characteristics.ObjectiveThis topic plans to take dialectical treatment to the knee osteoarthritis patients of Yang deficiency and congealing cold, aiming at the characteristics of knee osteoarthritis etiology and pathogenesis, taking the method of warming Yang and activating blood, with Guizhishaoyaozhimu Decoction and Huoluoxiaoling Dan decoction, clinical effect and safety of the treatment of such patients.MethodsThe60patients of the knee osteoarthritis of Yang deficiency and congealing cold, randomized controlled method divided into treatment group and control group, two groups of30cases. The treatment group with Guizhishaoyaozhimu Decoction and Huoluoxiaoling Dan Decoction orally, daily1agent, morning and afternoon each time; For the control group oral Glucosamine Hydrochloride Capsules (1/bid/day), Shujinhuoxue capsules (4/tid/day),4weeks for1courses. The observation period for1courses, record comparison before and after treatment, patients with clinical situation, the specialty special inspection (including grading and joint swelling, pain, dysfunction, and so on), as well as adverse drug reactions, and carries on statistics processing, compared before and after treatment, clinical efficacy and safety with warming Yang and activating blood circulation to the patients of the knee osteoarthritis of Yang deficiency and congealing cold.Results1. GuizhiShaoyaoZhimu Decoction and Huoluoxiaoling Dan Decoction in treating the patients of knee osteoarthritis of Yang deficiency and congealing cold and oral glucosamine capsule with Shujin Huoxue capsule, The total curative effect after statistics processing, P＜0.05, the difference has statistical significance.2. GuizhiShaoyaoZhimu Decoction and Huoluoxiaoling Dan decoction can obviously improve the patients of knee osteoarthritis of Yang deficiency and congealing cold with Lysholm knee score, TCM symptoms and pain VAS score. The total curative effect after statistics processing, P<0.01, the difference has statistical significance.3. In the clinical observation period, only1cases in the treatment group patients with drug early mild diarrhea, and relieved, other patients before and after treatment were not found to have obvious adverse reaction.ConclusionGuizhishaoyaozhimu Decoction and Huoluoxiaoling Dan decoction is effective and safe in treatment of the patients of knee osteoarthritis of Yang deficiency and congealing cold. And its efficacy is better than oral glucosamine capsule with Shujin Huoxue capsule.