Expression And Correlation Of Colorectal Cancer Tissue Of Her-2and MTA1

[Objective]Discussion of colon tissue expression of HER-2gene and gene MTA1. Both studies in colon cancer invasion, metastasis and clinical significance during the HER-2gene and gene mutual MTA1.[Method]50cases collected by the Affiliated Hospital of Yanbian University, surgical resection of colon cancer, No prior radiotherapy. chemotherapy and immune therapy;30cases of colorectal adenoma;Adjacent normal colon tissue20cases. Detected by immunohistochemical SP staining with HER-2expression in which MTA1and correlation analysis.[Results]Expression in colon cancer tissue HER-2was64%(32/50), adenomatous tissue HER-2expression was63.3%(19/30), adjacent normal colon tissue HER-2expression was25%(5/20).MTA1expression in colon cancer was58%(29/50), MTA1expression in colon adenoma tissue was56.7%(17/30), the expression of normal colon tissue adjacent the free MTA1. HER-2and MTA1expression rate in colon cancer and colon adenoma tissues was significantly higher than that in normal colon tissues,but there was no difference between colon cancer and colorectal adenomas. Expression of HER-2in colon cancer tissues and MTA1were associated with age, gender、 tumor size、degree of differentiation of patients with distant metastasis、CEA levels were not correlated (P>0.05), Duke’s stage colon cancer、lymph node metastasis (P<0.05). No significant correlation between HER-2expression in colon cancer tissue and MTA1(P>0.05).[Conclusion]MTAI with HER-2expression in colon cancer metastasis and may contribute to the progress of colon cancer, Combined detection of HER-2gene and MTA1gene can be judged as the invasion of colon cancer, screening important indicator of high-risk populations.