The Disscusion Of Pregnancy In Young Breast Cancer Patients After Treatment

Objective:To understand the status of pregnancy after breast cancer treatment and evaluate the effects of pregnancy subsequent to treatment on disease progression and survival in breast cancer patients.Methods:Medical records review of547breast cancer patients age≤35years in Tianjin Medical University Cancer Hospital between January2003and December2009. The median follow-up period was72months. Of these,291patients were excluded as no history was available regarding pregnancy. This study involved256patients was conducted to compare prognosis among breast cancer patients with and without a subsequent pregnancy. The pregnancy status, clinical and pathological characteristics were included and analyzed by statistical software SPSS19.0to calculate the relation with disease-free survival and overall survival. The clinical data were described by the percentage, Kaplan-Meier method for calculation of survival, Log-Rank method for the univariate factor analysis, COX model for multivariate factors analysis, and COX regression was used to estimate the hazard ratio of dying among women with a pregnancy after breast cancer treatment compared with women without such experience, with p<0.05defined as a statistically significant difference.Results:In all,45(17.6%) patients were pregnant after breast cancer treatment,in which8women experienced full term births and34abortions and3patients are in pregnancy. And,5abortions due to the unhealthy babies among the34abortions.The5years overall survival was100%for women experienced pregnancy and86.1%for women who did not (p=0.014). Univariate factor analysis results showed that the tumor size, nodal status and clinical stage were related with disease free survival (p <0.05), except the tumor size, the nodal status were also significantly related with overall survival. Multivariate factors analysis result indicated that status of the lymoph was independent factor of overall survival.Pregnancy after breast cancer treatment implied that it had no significant positive impact on overall survival.And the impact on overall survival has no different between patients who complete pregnancy and the abortion ones.Conclusions:The current study indicated that pregnancy was associated with a decreased risk of disease progression and even with the consideration of "healthy mother effect", we found no evidence that a pregnancy after treatment of breast cancer has a negative influence the prognosis.