Value Of Thinprep Cytologic Test (TCT) Combined With Colposcopy Examination In The Diagnostic Of Cervical Diseases

Objective:To evaluate the diagnostic value of Thinprep cytologic test (TCT) Combinedwith Colposcopy examination about Cervical Diseases.Methods:Choose between September2010and September2012in Yingkou cityWomen and Children’s hospital of obstetrics and gynecology clinics have clinicalsymptoms of1500cases of patients, aged between20-68, an average of34.7±4.3years,production times0to4times, the average production time (1.48±0.69), all patientswere not pregnant, has a history of having sex, and no surgical treatment for cervical,according to the doctor order divided into two groups, observation group (750cases) forTCT examination, then line biopsy under colposcope (the former results suggest theASC or higher); Control group (750cases) only colposcope examination and tissuebiopsy will find abnormal images. The observation group joint biopsy under colposcope(TCT) age was20-62, with an average of33.6±3.5years old, mean production timewas1.28±0.63; Biopsy under colposcopy in the control group (only) in patients withage distribution of27-68years old, average age was36.7±4.7,1.64±1.64. Twogroups of patient’s age and statistical analysis, there is no difference between (P>0.05).From all organizations will be sent to pathological examination, the examination resultsas the gold standard of diagnosis, the TCT combined colposcope examination andcolposcope examination only compare the comparative analysis, in order to evaluateliquid based cytology combined with colposcope examination in the diagnosis andtreatment of the role of cervical lesions.Results:1. Observation group results in abnormal was found for194cases, accounting for25.9%of the total (750cases), the significance of atypical squamous cells (ASC),117cases, accounting for60.3%(117/194), low-grade squamous intraepithelial lesions(LSIL)56cases,28.9%(56/194), highly squamous intraepithelial lesion (HSIL)20cases,10.3%(20/194), cervical cancer1case,0.5%(1/194); Image in different levels ofabnormal under colposcope, drawn after the biopsy, the results show that139cases withdifferent degree of pathological changes, including CINⅠ101cases, accounting for52.1%(101/194), CINⅡof29cases accounted for14.9%(29/194), CINⅢ8cases,4.1% (8/194),1case of cervical cancer patients,0.5%(1/194). TCT positive cases, thepathologic results of117patients with ASCUS in the diagnosis of precancerous lesionsin66cases, accounting for56.4%, the proportion of LSIL, HSIL and cervical cancergroup respectively for91.1%,95%,91.1%, the higher the degree of pathologicalchanges, TCT diagnosis level is higher, the higher the rate of cervical intraepithelialneoplasia, so should attach importance to the clinical significance of atypical squamouscells of the patients.2. Without the TCT, colposcopy examination, only will be abnormal vaginal mirrorimage at the same time patients based on biopsy, which only exist in the patients withbiopsy under colposcope abnormal patients of191cases, accounting for25.5%of thetotal (750cases)(191/750), with125cases of acetic acid white epithelium, accountedfor65.4%(125/191), white with epithelial dot vessels in48cases,25.1%(48/191),white epithelium with fuzzy set13cases,6.8%(13/191), hickies, white glandularabnormity of blood vessels, brain back in5cases,2.6%(5/191); Pathological histologyof58patients with abnormal detection, of whom42CIN Ⅰ,22%(42/191),10cases ofCINⅡ,5.2%(10/191), CINⅢ in5cases,2.6%(5/191),1case of cervical cancerpatients,0.5%(1/191).3.750cases based TCT combined biopsy under colposcope,194cases of TCT positive,TCT positive detection rate of25.9%,139cases of pathological histology diagnosispositive detection rate71.6%;750cases of patients with biopsy under colposcope, only191cases of abnormal vaginal mirror image, histologic diagnosis positive58cases, thedetection rate of30.4%, show significant difference between the comparative analysis, P<0.05). Liquid based cytology in combination with the results of the biopsy undercolposcope CINⅠ101cases (52.1%), CINⅡ,29cases (14.9%),8cases CINⅢ,4.1%,1case of cervical cancer patients,0.5%; Only on the result of the biopsy undercolposcopy in CINⅠ,42cases (22%),10cases of CINⅡ, accounted for5.2%, CIN Ⅲin5cases, accounted for2.6%,1case of cervical cancer patients, accounted for0.5%,two groups to compare the diagnosis of CIN is various aspects, according to the resultsof the former detection rate is high, the difference between the two there is no statisticalsignificance (P>0.05).Conclusions: For TCT positive patients, the higher the degree of pathological changes,TCT diagnosis level is higher, the higher the rate of cervical intraepithelial neoplasia, soshould pay attention to this part ASCUS patients clinically. Colposcope examinationwhich combines the line biopsy can make its detection rate increased significantly at thesame time, with only the colposcope statistical differences between the two groups tocompare the diagnosis of CIN is various aspects, TCT combined biopsy undercolposcope than only biopsy under colposcope detection rate is high, but the differenceis there is no statistical significance. So TCT combined colposcope examination, and atthe same time to reflect on biopsy to its accuracy in the diagnosis of cervical lesions.