Study On The Changes Of Serum Calcium, Phosphorus And Serum25Hydroxy Vitamin D During Fracture Perioperative

Objective To study the serum calcium, phosphorus and25hydroxy vitamin D[25(OH)D] changes and significance during fracture perioperative.Methods Prospective study from2012May to2013June,160patients with traumaticfracture operation in the Department of orthopedics, the First Affiliated Hospital ofDalian Medical University hospital patients were selected, in which77were Male,83were female; age30~90years, mean age (59.4±16.9) years;93cases were caused bylow energy injuries,67cases were Caused by accident or falling; the fracture wasoperated after1~5days. In the first day after fracture and operation the morningfasting serum calcium, phosphorus and25(OH) D levels were measured.Over the sameperiod outpatient selected150cases of healthy people as control group for statisticalanalysis.Results1. During perioperative serum calcium and phosphorus levels was decreasedcompared with those in the control group, postoperative serum calcium and phosphoruslevels was lower,than preoperative, the difference was statistically significant (P<0.05). Except for a little post-operative serum calcium levels outside below thenormal range, and the rest were within the normal range of fluctuation levels; Amongdifferent age and gender groups in serum calcium, phosphorus, the difference was notstatistically significant (P>0.05).2In the control group, preoperative and postoperativeserum25(OH) D levels and were (18.2±5.18) ng/ml,(12.24±7.46) ng/ml and (8.85±6.21) ng/ml. Perioperative significantly lower than the control group,32.7%of preoperative lower than the control group, after27.7percent lower than before thesurgery, the differences were statistically significant (P <0.05).3Serum25(OH) Dlevels decreased with age during perioperative and it in different age groups weresignificantly different (P <0.05)4. Female’s serum25(OH) D levels were significantlylower than men’s during perioperative, the difference was statistically significant (P<0.05)5. Low-energy trauma patients’ serum25(OH) D levels were significantly lowerthan high-energy trauma patients’ in30-group,the difference was statisticallysignificant (P <0.05); High-energy trauma patients’25(OH) D levels were significantlylower than low-energy trauma patients’ in50–group and70-group, the difference wasstatistically significant (P <0.05)7. Serum25(OH) D levels and serum calcium andphosphorus levels were not correlated during perioperative (P>0.05).Conclusion Vitamin D levels in the fracture is clearly insufficient, and furtheraggravated after surgery decreased vitamin D levels, which may consume or participatein fracture repair and related fractures. We should start after fracture sustainedsupplement adequate amount of calcium and vitamin D, and osteoporotic fracturesshould also be combined with anti-osteoporosis drugs.