Clinical Anaiysis Of Early Full-field ERG Changes In Cataract Patients After Implantion With Multifocal Intraocular Lens

Objective: This study investigates age related cataract patient after implantationwith different multifocal IOLs (blue light filtering multifocal IOL AcrySof ReSTOR SN6AD1and non-blue light filtering multifocal IOL TECNIS ZMB00).By comparingchanges in full-field ERG, influence factors of full-field ERG at the early postoperativestage can be effectively demonstrated. Furthermore, analyses the protection of blue lightfiltering IOL, and,also,provides a theoretical basis for the clinical application of bluelight filtering IOL.Method: Age related cataract who underwent phacoemulsification withimplantation of either AcrySof ReSTOR SN6AD1or TECNIS ZMB00wereincluded in this study. All the38patients (56eyes) had their surgical intervention at theDepartment of Ophthalmology of the Second Hospital of Dalian Medical University,from January2012to June2013. In accordance with the inclusion and exclusion criteriaafter selecting the IOLs,two groups were assigned randomly with the blue light filteringgroup (AcrySof ReSTOR SN6AD1) comprising of18cases (29eyes) while anothergroup including20cases (27eyes) was that of non-blue light filtering implantation ofmultifocal intraocular lens (TECNIS ZMB00). Both pre-and post-operatively(at onemonth and three month),the patients had full-field ERG examination in the time periodbetween14:00-16:00with recording of dark-adapted0.01ERG, dark-adapted3.0ERG, dark-adapted10.0ERG of a b-wave peak time, dark-adapted3.0oscillatory potentials ofthe peak time, light-adapted3.0ERG a b-wave peak time, light-adapted3.0flickerERG peak time and their respective amplitude test results. All data were analyzed byusing SPSS17.0software for statistical analysis.Results:1.TECNIS multifocal ReSTOR multifocal group compared with pre-operativefull-field ERG,the difference of all the indicators was not statistically significant(p>0.05).2.TECNIS multifocal group before and after surgery one month, three monthsafter the full-field ERG comparison, the implied gradually shortened, the amplitudegradually increased. Comparison of preoperative and postoperative at one month, thepeak time of light-adapted3.0b-wave, the amplitude of light-adapted3.0a-wave andb-wave (p<0.05).The difference of the other indicators was not statistically significant(p>0.05)In the preoperative and postoperative3-month comparison,dark-adapted0.01b-wave peak time, dark-adapted0.01b-wave amplitude, dark-adapted3.0b-wave peaktime, dark-adapted3.0a b-wave amplitude, dark-adapted10.0a-wave peak time andamplitude, dark-adapted10.0b-wave amplitude, dark-adapted3.0oscillatory potentialsamplitude, the difference was statistically significant(p<0.05).light-adapted3.0a b-wave peak time and amplitude, light-adapted3.0flicker amplitude,the difference wasstatistically significant (p<0.05). The peak time of dark-adapted3.0a-wave and b-wave,dark-adapted3.0oscillatory potentials,light-adapted3.0flicker (p>0.05)3.ReSTOR multifocal group before and after surgery one month, three monthsafter the full-field ERG comparison, the implied gradually shortened,the amplitudegradually increased. Comparison of preoperative and postoperative one month, light-adapted3.0a-wave and b-wave amplitude difference was statistically significant(p<0.05).The difference of the other indicators was not statistically significant (p>0.05).Comparison of preoperative and postoperative3months, the amplitude of dark-adapted0.01b-wave,dark-adapted3.0a-wave and b-wave,dark-adapted10.0a-wave and b-wave,dark-adapted3.0oscillatory potentials difference was statistically significant(p<0.05). The peak time and amplitude of light-adapted3.0a-wave and b-wave, theamplitude of light-adapted3.0flicker (p<0.05). The peak time of dark-adapted0.01b-wave,dark-adapted3.0a-wave and b-wave,dark-adapted10.0a-wave and b-wave, dark-adapted3.0oscillatory potentials and light-adapted3.0flicker(p>0.05).4.ReSTOR multifocal TECNIS multifocal group compared with the group afterthree months full-field ERG findings,the peak time of dark-adapted10.0a-wave andb-wave,the amplitude of dark-adapted10.0b-wave, light-adapted3.0b-wave andlight-adapted3.0flicker difference was statistically significant (p<0.05). The differenceof the other indicators was not statistically significant (p>0.05).Conclusion:1.Cataract surgery can better solve the lens opacity effects on retinal imaging asshown by postoperative full-field ERG with peak time shortening and amplitudeincreased.2.Multifocal intraocular lens show full-field ERG with delay peak time, decreasedcontrast sensitivity, and gradual light scattering after surgery.3.Blue light filtering intraocular multifocal IOLs, within a small sample, show aprotective effect on the inner layer of the retina and macula at3months follow-up.4.Blue light filtering IOLs reduce some blue light absorption and decrease contrastsensitivity in dark environment.