The Positive Effect Of Edaravone On Hepatic Ischemia Reperfusion Injury

ObjectiveStudy of edaravone in hepatic ischemia-reperfusion injury on hepatic injection tube after the protective effect. To observe and analyze the feasibility of protective effect of edaravone on liver injury by hepatic ischemia—reperfusion injury; These finding will provide a basis for clinical application.Methods54healthy SD rats were randomly divided into3groups:sham operation group (group A), ischemia/reperfusion group (B group), the intervention of edaravone group (group C),18rats in each group. Rat liver ischemia reperfusion model for occlusion of the hepatic portal30min, were measured reperfusion after2hours,4hours,6hours of liver alanine transaminase (ALT), aspartate aminotransferase (AST), xanthine oxidase (MDA), superoxide dismutase (SOD), and the levels of TNF-aResultCompared with A group, C group at each time point were visible on ALT, AST, MDA significantly increased, and SOD decreased (P<0.05),.Compared with group B, in group C after reperfusion for2,4,6h, ALT, AST, MDA value was significantly reduced, and SOD increased (P<0.05). The levels of TNF-α in liver and tissue in group B were significantly higher than those in group A(p<0.05). In group C, the levels of TNF-α in tissue were significantly lower compared with those in group B. The difference was significant(p<0.05).Conclusion1Edaravone has protective effects on liver injury induced by hepatic ischemia-reperfusion in rats.2The mechanisms of the effect of Edaravone on the hepatic I/R are maybe due to the ability of clearing the free radicals, inhibiting lipid peroxidation and then restricting TNF-α response indirectly.