Study Of The Relationship Between Serum Level Of25-hyaroxyvimmin D3and Diabetic Peripheral Neuropathy

ObjectiveTo investigation the relationship between serum level of25-hyaroxyvimminD3and diabetic peripheral neuropathy, in order to explore new treatment fordiabetic neuropathy.Subjects and MethodsThe data are from the inpatients who were diagnosised with type2diabetesmellitus (T2DM) in the First Affiliates Hospital of Zhengzhou University fromNov the1st,2012to June30,2013.The diagnosis of the T2DM is correspond todiagnositic criteria made by Word Health Organization (WHO) in1999.According to neuropathy symptom scores (NSS)、nerve conduction studyscores （NCS） and nerve electroneurogrm, they were divided into DNP groupand NDNP group. In the NDNP group,there are38cases (26male and12female) with mean age56.65±12.73years old,in the other group,there are63cases(32male and31female) with mean age49.55±12.19years old, Somecases who are heavy smokers，heavy drinkers, suffered from these below diseases: endocrinology disease, liver and kidney disfunction, infection,acutecomplication of diabetes, primary osteoporosis, cancer, autoimmune disease, inrecent one year have taken medications affecting bone metabolism, peripheralneuropathy with other reason (such as cerebrovascular disease,herniated disk,cervical spondylosis, nerve root irritation and chrnic alcoholism). Asking thequestions about the patients symtoms and the past health, testing the level of theserum25-(OH)D3and nerve electroneurogrm. Compare the level of serumvitamin D in two groups;Compare the proportion of25-(OH)D3deficiency inthe two groups; logistic regression analysis to study the relationship betweenDiabetic peripheral neuropathy and other factors. If P<0.05, there’s statisticalsignificance.Results1. According to the NSS scores、NDS scores and nerve electric group of all thepatients,there are63cases in the DNP group, accounting for62.4%of all thecases, there are38cases in the DNP group, accounting for37.6%of all thecases,2. The DNP group had a significantly higher age, duration, HBA1C than NDNPgroup,(P <0.05), fasting C peptide is lower than NDNP group (P <0.05), sexratio, BMI, blood serum creatinine, blood PTH, calcium, phosphorus of the twogroups had no statistical difference.3. Compared basic data in the two groups,In DNP group,69.8%of patients hadvitamin D deficiency compared with57.8%of patients in NDNP Group(P<0.05), It was statistically different beween the level of serum25-(OH)D3inDNP group and that in NDNP group.4. The logistic stepwise regression analysis showed that25-(OH)D3, fasting Cpeptide are negative correlation with diabetic peripheral neuropathy,HBA1C,diabetes duration are positively correlation with diabetic peripheralneuropathy. Conclusion1. The serum25-hydroxyl vitamin D3level in DNP group is significantly lowerthan the NDNP group,the proportion of the patients with25-(OH)D3deficiencyin DNP group is higher than that in NDNP group.2. The level of serum25-(OH) D3of the patients with type2diabetes had anegative correlation with diabetes peripheral neuropathy3. This study showed that vitamin D playde an important role in the occurrence anddevelopment of Type2diabetes and diabetic peripheral neuropathy, Maybevitamin D supplements could improve diabetic peripheral neuropathy.