The Serum Des-gamma-carboxy Prothrombin Level And Its Clinical Significance

ObjectiveThe aim of this study was to determin the prognostic value of DCP in HBV-related HCC. We detected the serum DCP level in patients with HBV-related HCC. Then we explored the association between serum DCP and clinicopathological factors of patients with HCC, and furthermor we analyze the relationship between the serum DCP and prognosis of patients who underwent radical surgery.MethodSerum DCP were determined by enzyme immunoassay with a double antibody sandwich system in192patients with HBV-related HCC. The relationship between serum DCP and clinicopathological factors were studied. Kaplan-Meier method, Log-rank method and Cox model were used to determine the relationship between serum DCP and the prognosis of patients with HBV-related HCC who underwent radical resection.Result1. Serum DCP level was not correlated with serum AFP level(r=0.342, P=0.251).2. Serum DCP level was significant correlated with HBV-related patients’ clinicopathological characteristics such as tumor size (P=0.012), tumor numbers (P=0.002), microvascular invasion(P=0.013), portal vein thrombus (P<0.001), TNM stage (P=0.004), but not patients age, gender and tumor grade (P=0.190).3. A total of112patients with HBV-related HCC underwent radical resection. Univariate analysis showed that the level of serum DCP>100mAU/ml (absent VS present,81.8%VS54.5%, P=0.007), tumor size>3cm (absent VS present,93.1%VS64%, P=0.02), microvascular invasion (absent VS present,85.9%VS61%, P=0.022), advanced TNM stage (Ⅰ+Ⅱ VS Ⅲ+Ⅳ:80.7%VS51.9%, P＜0.001) and tumor recurrence (absent VS present,78.45%VS50.23%, P=0.008) was risk factors for poor3-years survival. Multivariate analysis showed that serum DCP>100mAU/ml (HR:2.165,95%CI:1.048-4.521, P=0.047), microvascular invasion (HR:1.742,95%CI:,1.016-4.326, P=0.048) and TNM stage (HR:2.316,95%CI:1.125-4.770, P=0.023) were independent risk factors for HCC. Conclusion1.Serum DCP level was not correlated with serum AFP level.2.Serum DCP level was significant correlated with patients’clinicopathological characteristics such as tumor size, tumor numbers, microvascular invasion, portal vein thrombus and TNM stage.3.High serum DCP level is an independently prognostic factor in HBV-related HCC patients after radical surgery. It may be a prognostic factor of HBV-related HCC.