Notoginseng Diet Observation Of The Clinical Curative Effect Of Primary Glomerular Hematuria

ObjectivesTo observe the result of notoginseng diet on the parameters of primary glomerular hematuria patients. To evaluate the effect and security of notoginseng diet therapy in reducing blood in the urine and clinical symptoms. To search a new simple and economic method from traditional Chinese medicine to relieve patients’symptoms, delay the hematuria progress provides, and then improve the effect of dialysis and the quality of life.MethodsTo select patients according to the diagnostic standard, inclusion criteria, exclusion criteria. To group the patents into the notoginseng group and the control group according to their own will whether to accept notoginseng diet. All patients will be given basic treatment. In addition, the notoginseng group patients will be told to add3gram notoginseng flour in their daily diet, which should be taken for4weeks. Then all parameters of the patients will be evaluated before and after the treatment. The main parameter is ery. The secondary parameters are sympotom scores of TCM and quality of life. The security parameters are urine protein. To analyze and evaluate the clinical curative effect and feasibility of notoginseng diet, and discuss the possible mechanism of action.Results33patients were enrolled in the study. They were grouped into the notoginseng group and the control group according to their own will. There were17patients in notoginseng group and16patients in control group. During the study, two patients in the notoginseng group were excluded because of pulmonary infection and personal reasons respectively. In control group, there was one patient withdrew from the study for evection. The two groups were well balanced in all conditions including age, sex, ery, scores of traditional chinese medicine symptoms and the quality of life, etc.After the intervention, the urine blood was significantly reduced in the notoginseng group(P<0.05), and there was no significant difference in the control group(P>0.05). Compared with the matched group, the difference was statistically significant (P<0.05).On the aspect of TCM symptoms scores, the notoginseng group relieved than those at the beginning, and gained significant differences in the following symptoms--dizziness, tired, thirsty, soreness and weakness of waist and knees, and poor appetite (P<0.05). There was no significant difference in the other TCM symptoms scores in the control group (P>0.05).In terms of quality of life, comparing with pre-intervention, Two group have improved in quality of life. Notoginseng compared with the matched group, there was statistically significant difference in:Physiology, body pain, general health, energy, and mental health, etc. and those parameters of two group significantly ascended after8weeks (p<0.05). Comparison of the changes in those parameters, they all had significant differences between the two groups (p<0.05). And the difference has statistically significant difference in the two groups before and after intervention in four dimensions of quality of life:body pain, general health, energy, and mental health (p<0.05).On the aspect of security parameters, there were no significant differences were found in the urine protein before and after intervention.Conclusion1、Notoginseng diet can effectively alleviate the symptoms of patients with primary glomerular hematuria urine. The modern research mechanism may be related to the relife of glomerular high coagulation state in patients after notoginseng diet, and the glomerular cells have been repaired, and the immune complex deposition have been reduced.2、The notoginseng diet relieved the symptoms of TCM. The symptons have improved appearently in dizziness, tired, thirsty, soreness and weakness of waist and knees, and poor appetite. It was considered that by way of Invigorate the circulation of hemostatic, improving liver and kidney function, and makes the bones and muscles stronger, and adjust the five internal organs function,.3、The notoginseng diet can improve the quality of life in patients with Primary glomerular hematuria. The mechanism may be related to the promotion of blood circulation, then enhance the immunity and improve cells and the viscera function, balance the body to environmental factors.4、In the application of notoginseng diet, no adverse reaction was observed. It has the characteristics of convenient, safe, economic and effective, more in line with the concept of self management of patients with chronic kidney disease (CKD),. Therefore, notoginseng diet are worth popularizing and applying to clinc.