The Effect Of Traditional Chinese Medicine (TCM) Yin Xie1Hao On In Vitro Cultured Neutrophils Secreted NE、trappin-2

ObjectiveNow mainly concentrated on the study of psoriasis in T cells, lymphocytes, although there are some people began to study the neutrophils, but a few. But as the latest study found that, in fact, those who have the neutrophils invasion detected is a lot of. It is considered one of the major effector cells are nonspecific inflammation reaction, and can affect the psoriatic condition of many of cytokines secreted by the neutrophils. Then, through the neutrophil elastase (neutrophil elastase, NE) of in-depth study, through which we can gain a better understanding of the neutrophils. NE of the inhibitors for trappin-2, they are the two with psoriasis was closely related to two factors. So someone put forward NE/trappin-2is imbalance can cause psoriasis.We are from the above, the contents of the associated with the traditional Chinese medicine treatment of psoriasis is effective, traditional Chinese medicine for treating psoriasis is also can affect the secretion of neutrophils NE and its balance with trappin-2?Despite the above conjecture, but if no one is really study published in some magazines. So we through the study of different concentration of traditional Chinese medicine compound1silver crumbs drug-containing serum on in vitro cultured neutrophils secreted NE, the influence of trappin-2, and, if can be trappin-2in the human body does not meet the normal balance is related to the severity of the disease, from here we explore explain their role in the disease inside mechanism. To elucidate the pathogenesis of psoriasis, traditional Chinese medicine (TCM) silver crumbs party1"from the blood" to elucidate the role of with psoriasis vulgaris inner material base, to establish the compound Chinese medicine treatment of new targets with psoriasis vulgaris provide more sufficient scientific basis, to explore the etiology, pathogenesis of psoriasis and psoriasis treatment provides a new train of thought.MethodsFrist, Collection of18cases of patients with psoriasis vulgaris, the clinical and pathological diagnosis. Peripheral blood using lymphocyte separation medium density gradient separation of neutrophils. Using trypan blue dyeing experiments were identified cells purity and activity. Vaccination on the culture plate. Second, In neutrophils medium, the experimental group4concentration of Traditional Chinese medicine (TCM) yin xie1hao,1more than control group in tripterygium wilfordii glycoside, physiological saline, above to join for the drug-containing serum, cultivate48hours, by using ELISA method to detect the in vitro cultured neutrophils secreted NE, trappin-2expression level. Compare the differences between groups, experiment exploring TCM compound1silver crumbs to patients with psoriasis vulgaris in vitro cultivation of neutrophils secreted NE, the influence of trappin-2, further observation NE/trappin-2balance relations with psoriasis.ConclusionTraditional Chinese medicine (TCM) yin xie1hao May inhibit the expression level of NE in neutrophils secretion, and inhibit trappin-2expression level, which regulates NE and NE inhibitors trappin-2, keep the balance, so as to achieve therapeutic effect. This shows that Chinese medicine can treat psoriasis, and its effect is very good. Psoriasis patients can make life better, more free and happy.