Rosuvastatin On Occurrence Of Atherosclerosis In Hypertension Accompanied LDL-C Slightly Increased

Objective To evaluate the effect of rosuvastatin on the occurrence of atherosclerosis inpatients with essential hypertension accompanying LDL-C slightly-increased, as well as therelevance between the IMT of carotid artery, ratio of LDL-C/HDL-C, ankle-brachial indexand arteriosclerosis, respectivelyMethods189hypertensive patients with slightly-increased LDL-C in JiNing FirstPeople’s Hospital from August,2011to Feburary,2013were selected and randomly assigned tothree groups: the low does group, the high does group and the control group. There are63cases in each of the groups. Only antihypertensive treatment was given to the members of thecontrol group, and different does of rosuvastatin were given to the other two groups on thebasis of the antihypertensive treatment: rosuvastatin10mg, one does per night for the lowdoes group; rosuvastatin20mg, one does per night for the High does group. Before theexperiment, all the patients were instructed to have balanced diets, moderate exercise,controlled weights and regular blood pressure tests. During the experiment, the clinicservice-visit was given to the patients every three monthes for follow ups. All theantihypertensive medicine used in the experiment are tier-one products including calcium、diuretic、β-blocker、calcium、ACEI、ARB. For the hypertensive patients who do not respondto one type of antihypertensive medicine, we gave them joint antihypertensive treatments withover two types of medicine. The goal blood pressure level of the treatment is below140/90mmHg. All the patients in the experiments were ruled out the following conditions:Secondary hypertension caused by pheochromocytoma、primary aldosteronism、renal arterystenosis etc; Hypertension that cannot be controlled by medicine; Severe liver functiondamage（AST/ALT is greater than or equal to1.5times normal limit；Cardiac failure（NYHAClassⅢ–Ⅳ）, pregnancy, malignant tumor, hyperthyroidism, diabetes, Structural heartdiseases. The ratio of LDL-C/HDL-C, IMT of carotid artery and ankle-brachial index were measured1week before the experiment,3months、6months and9months after the beginningof the experiment, respectively in order to anticipate the occurrence and development ofatherosclerosis in patients.Results1、After the experiment, the ratio of LDL-C/HDL-C of all the groups decreased.Compared with the control group, the ratio of LDL-C/HDL-C of the other two groupsdecreased significantly (p<0.05). The ratio of LDL-C/HDL-C of high does group decreasedmore significantly than that of the low does group from6th month of the experiment(p<0.05).2、Compared with the control group, the IMT of carotid artery of the other two groupswith the rosuvastatin treatment decreased gradually and significantly(p<0.05).Although theIMT of carotid artery of low does group and high does group decreased, the difference wasnot significant (p<0.05),before the9th month of the experiment. However, it seemed that thehigh does group worked better than the low does group and after the9th month of theexperiment, the difference between the two groups became significant(p<0.05).3、The rosuvastatin treatment can also decrease the ankle arm index of patients withessential hypertension accompanying LDL-C slightly-increased.4、The rosuvastatin treatment can effectively reduce the occurrence and development ofatherosclerosis in patients with essential hypertension accompanying LDL-Cslightly-increased, and the high does works better.ConclusionsFor the patients with essential hypertension accompanying slightly-increased LDL-C, therosuvastatin treatment can decrease the ratio of LDL-C/HDL-C significantly and the highdoes works better.The rosuvastatin treatment can also decrease the IMT of carotid artery of patients withessential hypertension accompanying LDL-C slightly-increased effectively and the high doescan significantly decrease the IMT of carotid artery.The rosuvastatin treatment can also decrease the ankle arm index of patients withessential hypertension accompanying LDL-C slightly-increased.The rosuvastatin treatment can effectively reduce the occurrence and development of atherosclerosis in patients with essential hypertension accompanying LDL-Cslightly-increased, and the high does works better.