The Correlation Study Of Liver Fat Content And Metabolic Syndrome

Objective:To explore relationship and related risk factors of liver fat content with ultrasound and metabolic syndrome and its components.Methods:1. A total of200subjects were recruited in Tianjin during Mar.2011to Feb.2012. All subjects have no diabetes history; no severe kidney diseases; no tumors; no severe psychiatric disorders; not used drugs which maybe affect glucose metabolic before and under one month investigation; no chronic viral hepatitis, no autoimmune liver diseases, drug-induced liver disease and other liver diseases due to hereditary diseases, no abundance alcohol drinking. All subjects have no hypoglycemic therapy, and have no changes of types and doses of lipid and hypotensive drugs the last one month.2. Records the following informations:(1) Demographic data:age, sex, past medical history;(2) General physical examination informations:(J)Height, weight, waist circumference, hip circumference, and body mass index and waist hip ratio were calculated;②Systolic blood ptessure (SBP), diastolic blood ptessure (DBP);(3) Laboratory parameters:①Biochemical indicators: triglyceride(TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), alanine aminotransferase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (y-GGT), urea nitrogen (BUN), creatinine (Scr), serum uric acid (SUA);②To oral glucose tolerance test, determination of fasting plasma glucose (FPG),2hour plasma glucose(2hPG), fasting insulin (FINS), the steady-state model method was used in calculating insulin resistance index(HOMA-IR);(4) Acquisition liver and kidney B ultrasonic image,and calculate the liver fat content;3. Subjects were divided into four groups according to LFC Quartile.Results:1. According to LFC Quartile, four groups were divided into Quartile1(LFC<9.19%), Quartile2(9.19%≤LFC<14.28%), Quartile3(14.28%≤LFC<26.38%), Quartile4(LFC≥26.38%); BMI, waist circumference, WHR, SBP, DBP, TG, TC, LDL-c, ALT, AST, ALP, γ-GGT, FPG,2hPG with increasing LFC showed a trend of increase, HDL-c showed a trend of decrease. Quartile4of BMI, waist circumference, WHR, DBP, TG, TC, LDL-c, ALT and AST were significantly increased compared to the other three groups (P<0.01or P<0.05); SBP, y-GGT, FPG,2hPG of quartile4than Quartile1and Quartile2increased significantly (P<0.01or P<0.05); ALP of Quartile4than Quartile1increased significantly (P<0.05); Quartile3in age, BMI, waist circumference than Quartile1increased significantly (P<0.01or P<0.05);2hPG of Quartile3group than Quartile1and Quartile2increased significantly (P<0.05); HOMA-IR of Quartile4than Quartile2is significantly higher (P<0.05);2. LFC in the diagnosis of nonalcoholic fatty liver disease (NAFLD), the area under the ROC curve was0.862(P<0.01), the best threshold of17.282%, the sensitivity was80%, specific degrees was80%;3. Prevalence of MS and its components are increased along with the increase of LFC(P<0.05);4. Using binary Logistic regression, gender, waist circumference,2hPG to MS for the dependent variable regression equation (P were0.008,0.005,0.014);5. Using binary Logistic regression, LFC respectively to obesity, abnormal lipid metabolism, abnormal glucose metabolism as the dependent variable regression equation (P were0.004,0.021,0.013).6. Correlation analysis shows, LFC positively correlated with SBP, DBP, BMI, waistline, WHR, FPG,2hPG, TC, TG, LDL-c, HOMA-IR, ALT, AST, ALP, y-GGT(P<0.01, P(HOMA-IR, ALP)<0.05); and negatively correlated with HDL-c(P<0.05);7. Multiple linear regression analysis, the results show the waist circumference, ALT into LFC as the dependent variable regression equation(P were0.041,0.002).Conclusion:With the increase of the LFC, the prevalence of MS and its components showed a trend of increased significantly; Gender, waist circumference,2hPG are independent risk factors of MS; LFC is independent risk factor of obesity, abnormal lipid metabolism, abnormal glucose metabolism; Waist circumference and ALT is risk factors for LFC; LFC and MS, obesity, abnormal lipid metabolism, abnormal glucose metabolism influence each other, interact with each other centered on IR; LFC in the diagnosis of NAFLD best threshold is17.282%, and more senstitive than ultrasonic qualitative diagnosis.