Clinical Investigation Of Lung Disease In Systemic Lupus Erythematosus

Objective:To analyze the incidence, clinical features, and prognosis of lung lesions in patients with systemic lupus erythematosus.Methods:1640SLE inpatients were analysed with regards to clinical manifestations, imaging features and laboratory test results between2003and2013in our hospital.Results:Pulmonary involvement occurred in694cases with an incidence rate of42.32%. The incidence of Pleurisy and pleural effusion was23.29%, the clinical manifestations were chest pain, breathing difficulties and cough. The incidence of pulmonary infection was10.12%and Pathogenic bacteria mainly included pseudomonas aeruginosa, candida albicans, tuberculosis bacilli, Staphylococcus aureus, Escherichia coli and klebsiella pneumoniae. The incidence of Chronic interstitial lung disease was6.16%and the clinical manifestations were breathing difficulties, fever and cough. CT images manifestations were lung bottom grid-based changes, ground glass-like changes or honeycomb changes. The incidence of Pulmonary hypertension was5.24%, Often associated with Raynaud’s phenomenon, interstitial lung disease, pericardial effusion, anti-cardiolipin antibodies positive. The incidence of Diffuse alveolar hemorrhage was0.85%, the X-ray or CT showed emerging diffuse symmetric, ground-glass kind of patchy, often associated with kidney damage. The incidence of Pulmonary embolism was0.30%and breathing difficulties was the main performance. ECG and chest X-ray was often abnormal. The incidence of Acute lupus pneumonitis was0.18%and all patients experience symptoms of fever, breathing difficulties, cough, and hypoxemia. The incidence of shrinking lung syndrome was0.1%, Chest B-Tip showed unilateral or bilateral diaphragmatic elevation and range of motion reduce.Conclusions:Lung is often involved in patients with SLE and its overall incidence is high with a variety of clinical manifestations and more common in women. The average age of pulmonary involvement is higher than the without and two groups are no differences in sex ratio. Imaging features and laboratory test results contribute to early detection and diagnosis. These also can be used as important indicators of treatment response assessment. The number of deaths of pulmonary involvement was significantly higher than the without. The main causes of death were pulmonary infection and diffuse alveolar hemorrhage. The therapy of using corticosteroids or combined with immunosuppressive agents is effective.