| Objective: breast cancer is one of Female common malignancy，the incidenceis a growing trend, with chemotherapy and hormonal therapy, targeted therapyapplications, the mortality rate decreased significantly, five DFS (disease freesurvival) of breast cancer has been to more than75%. With the development ofmolecular biology, there are a large number of joint research on Ki-67, p53, EGFR,CK5/6single indicator or two indicators, less comprehensive study of a number ofindicators reported above indicators in guiding the choice of chemotherapy,endocrine therapy, targeted therapy and prognosis and outcome plays an importantrole in this paper, a comprehensive analysis of the major estrogen receptor (ER, PR),human epidermal receptor (HER-2), Ki-67antigen, p53gene, epidermal expressionof growth factor receptor (EGFR), correlation analysis correlation CK5/6protein eachother, and between the clinical and pathological features of breast cancer, and toexplore the different ages of breast cancer and triple negative breast cance situation.Methods： April2012-December190breast cancer patients in Dalian MedicalUniversity breast surgery, complete pathological data, selected cases were female,aged30-89years old have a median age of52years, of which81cases≤50yearsof age,＞50years of age109cases. Breast cancer diagnosis and classificationaccording to WHO criteria[1], in which165cases of non-invasive specific cancer:162cases of invasive ductal carcinoma,3cases of invasive lobular carcinoma;17cases of invasive carcinoma of special type are as follows:6cases of papillary cancer, three cases of lobular carcinoma,5cases of mucinous carcinoma,1case ofpapillary paget,2cases solid neuroendocrine carcinoma; non-invasive cancer:11cases of intraductal carcinoma. Histological grading: I level in20cases.89cases ofClass II, Class III81cases. TNM staging: tumor size: T1(T≤2cm)101cases, T2(2cm＜T≤5cm)75caces,T3(T＞5cm)14cases; lymph node metastasis: Notransfer117cases,73cases of metastasis;,68cases of stage I,98cases of stage II,24cases of stageIII,0cases of stage IV.For ER, PR, Her-2, Ki-67, p53, EGFR,CK5/6data collation, Excel2003data entry, using SPSS17.0statistical package fordata processing.Results：1ER, PR, HER-2, ki-67, p53, EGFR and CK5/6positive expressionrate of190cases of breast cancer patients was,respectively74.21%(141/190)63.15%(120/190),41.05%(78/190),85.26%(162/190),63.15%(120/190),44.73%(85/190) and9.47%(18/190).2ER and the patient’s age, histological grade correlated (X2=3.900P=0.048, X2=16.539P=0.000); PR, ki-67and histological grading correlated (X2=16.000P=0.000, X2=18.279P=0.000), PR, Ki-67antigen positive rate lower;HER-2and tumor size, histological type and clinical stage were correlated (X2=14.152P=0.001, X2=14.181P=0.000, X2=18.279P=0.000), had a statisticallysignificant difference (P＜0.05); P53with lymph node metastasis, histological gradecorrelated (X2=4.341P=0.037, X2=7.120P=0.028); EGFR expression with age,tumor size, histological type, axillary lymph node status, histologic grade, clinicalstage no correlation (P＞0.05); CK5/6with lymph node metastasis were correlated(X2=3.977P=0.046)had a difference statistics significance (P＜0.05).3ER and PR positive correlation (r=0.694P=0.000), and Ki-67,EGFR negative correlation (r=-0.143P=0.049, r=-0.244P=0.001); PR andEGFR, CK5/6negative correlation (r=-0.332P=0.000); Ki-67positive correlationwith P53into (r=0.144P=0.047); EGFR and P53positive correlation (r=0.237P=0.006); CK5/6and EGFR positive correlation (r=0.179P=0.014). HER-2and ER,PR, Ki-67, P53, EGFR, there was no correlation with CK5/6;4Ki-67at age＜35years,50-60years old,＞positive rate in60 years were100%,86.1%,83.9%; P53at age＜35years,50-60years old,＞60years were positive rate:70%,65.5%,57.1%. With the younger stages, Ki-67, P53-positive rate is elevated, whereas with increasing age, the positive rate is reduced;5Ki-67, P53TNBC and the relationship with NTNBC the resultsshowed that Ki-67, P53expressed in TNBC and NTNBC respectively as follows:X2=3.906P=0.048, X2=0.029P=0.864;6EGFR and CK5/6and NTNBC expressed in TNBC, werestatistically significant (P＜0.05), which has its EGFR significantly difference wasstatistically significant (P＜0.01).Conclusions：1ER, PR, HER-2, Ki-67, p53, EGFR and CK5/6and patient age,tumor size, lymph node metastasis, histological type, histological grade, clinicalstage, there is a certain relationship.2patients younger, less lymph node metastasis, the lower ER-positive rate, the lower the degree of malignancy; ER and Ki-67negativecorrelation, ie, the higher the ER-positive rate, the lower the Ki-67proliferationindex. Ki-67positive correlation with P53, EGFR and CK5/6, increasing with eachother increased.3breast cancer in young and elderly breast cancer in youngbreast cancer ki-67positive rate of breast cancer in the elderly; in triple negativebreast cancer and non-triple negative breast cancer, EGFR and CK5/6expressiondifference was statistically significant (P＜0.05).Due to the small sample size, sample size and the need to increase in the futurebased on ER, PR, HER-2and P53, Ki-67and EGFR, CK5/6.As a result, patientswere followed up DFS and OS. |
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