The Effect Of Deferiprone And Clioquinol On Ferric Iron Transporters And Functional Outcome In Intracerebral Hemorrhage Rats

Objective: To observe the effect of deferiprone and clioquinol on the ferritin(Ft)/transferrin (Tf)/transferrin receptor(TfR) and functional outcome in intracerebral hemorrhage rats in the ironoverload condition at different periods.Methods:96Wistar rats Were randomly assigned to Different groups. They were received aninfusion of Collagenase Ⅳ into the right basal ganglia and were killed and evaluatedneurological function score at1/3/7/14day.Brain Ft/Tf/TfR around hematoma were examined byimmunohistochemistry.Results Compared with the operation controls，the expression of Ft were increased at3day,7day,14day in ICH，and reached a plateau at7day. The expression of Tf in all groups and Tfr at1day,3day,7day increased in ICH,and they reached a plateau at3～7day in ICH．DFP/CQ hadThe same trends but the increase were smaller than ICH. The neurological function score ofICH/DFP/CQ in all groups were increased significantly, the3day up, then gradually decreased.the increase of neurological function score of CQ were smaller than ICH and DFP.Conclusion Deferiprone and clioquinol may reduce the expression of Ft, Tf, TfR afterintracerebral hemorrhage by chelating iron, but deferiprone can not improve the nervedysfunction and clioquinol can improve it;the upregulation of Ft/Tf/TfR After intracerebralhemorrhage by itself may play a neuroprotective effect.