The Main Clinical Characteristic Of Pathology In Children’s Congenital Testicular Remnants

Aim:The formation and descent of the testicle is a complex embryologic event with the potential for a variety of parenchymal anomalies. About5%of congenital cryptorchidism manifest clinically as an empty scrotum, and the undescended testicles can’t be touched in scrotum or groin,or the testicles can be touched as a small dubious nodule.By the laparoscopic or Inguinal exploration, the testicular remnants at the end of Spermatic cord vessels and vas deferens can be found such as soya bean size. The conventional resection of these testicular remnants is controversial.By the histologic and immunohistochemical study of a group of testicular remnants of children with testicular regression syndrome(TRS) in the past5years,We aimed to summarize the main clinical characteristic of pathology of TRS and provide the basis whether testicular remnants should be removed.Methods:At the department of pediatric urology and oncology afiliated Children’s Hospital of Medical School of Zhejiang University,136surgical pathology specimens from142patients with this clinical diagnosis underwent scrotal exploration. Histologic and immunohistochemical comparison was done with5surgically removed teratoma of testis,1fetal testis. Results:Routine histologic studies showed fibrosis in all (136,100%), calcifications in75(55%), and hemosiderin deposits in41(30%),no seminiferous tubules in127cases (93%).9cases (7%) all less than6years old with seminiferous tubules were done by immunohistochemical study, germ cells were present in3(2%) cases all less than4years old.LNeither malignant cell nor precancerous lesionwas found.Conclusion:The main characteristic of pathology in children’s congenital testicular remnants were fibrosis, calcifications, and hemosiderin deposits. Only a relatively small number of cases contains parenchyma cells, sertoli cells vanished after6years old and germ cells that may grow into malignant tumour vanished after4years old. Neither malignant cell nor precancerous lesion was found.