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High Expression Of Polymeric Immunoglobulin Receptor Correlates With Hepatic Metastasis And Poor Prognosis In Patients With Colon Cancer Hepatic Metastasis

Posted on:2015-10-09Degree:MasterType:Thesis
Country:ChinaCandidate:S K ZhouFull Text:PDF
GTID:2284330428483294Subject:Surgery
Abstract/Summary:PDF Full Text Request
BackgroundIncreased expression of polymeric immunoglobulin receptor (pIgR) in tumor tissue has been detected in various cancer forms. However, the clinical relevance of pIgR in colon cancer hepatic metastasis remains uncertain. The aim of this study was to assess the prognostic value of pIgR in patients with colon carcinoma hepatic metastasis after hepatic resection.MethodspIgR expression was evaluated by immunohistochemistry in paraffin-embedded primary colon carcinoma and paired hepatic metastasis tissues from136patients with liver metastasis from colon carcinoma who underwent hepatic resection. The relation between pIgR expression and clinicopathologic factors and long-term prognosis in these136patients was retrospectively examined. The prognostic significance of negative or positive pIgR exspression in colon carcinoma hepatic metastasis was assessed using Kaplan-Meier survival analysis and log-rank tests.ResultsThe expression of pIgR in liver metastasis of colon cancer tissue was higher than in colon cancer tissue. This study indicated significantly worse overall survival (OS) for patients with a positive pIgR expression in colon carcinoma hepatic metastasis than for patients with a negative pIgR expression.ConclusionPositive expression of plgR was statistically significantly associated with poor prognosis of patients with colon carcinoma hepatic metastasis. plgR could be a novel predictor for poor prognosis of patients with colon carcinoma hepatic metastasis after hepatic resection.
Keywords/Search Tags:colon carcinoma, hepatic metastasis, polymeric immunoglobulin receptor(pIgR), prognosis
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