The Application Of Hs-CRP Combined With ABCD2Score In The Clinical Prognosis Of Transient Ischemic Attack

Background:Transient ischemic attack ((ischemic the transient attack, TIA) is a common type of ischemic cerebrovascular diseases, TIA is a important risk factor of ischemic stroke. The main pathogenesis of TIA is that the thrombosis is off from the surface of artetnerosclerotic plaque, another reason is that the atherosclerosis cause vessel lumen stenosis, and that lead to neurological dysfunction in the brain, regional cerebral ischemia. The tool for clinical evaluation of patients with transient ischemic attack is ABCD2score, the assessment tool is based on clinical symptoms and past medical history, the score and the clinician mastery and patient factors have a great relationship, so there are some limitations. In recent years neural biochemical markers research has made corresponding progresses, they began to provide information for the diagnosis, treatment and prognosis of cerebrovascular disease, and related studies suggest that inflammation play an important role in atherosclerotic, high sensitivity C-reactive protein can be as a marker of inflammation in ischemic cerebrovascular,and the high sensitivity C-reactive protein has become the focus of research.Purpose:we test the Hs-CRP of TIA patients,we study the clinical application value of Hs-CRP in TIA patients, and we analysis the ABCD2+Hs-CRP score’s use in evaluation of transient ischemic attack.Method:We selected patients in our hospital nerve internal medicine ward, interventional medical ward in the hospital diagnosed of internal carotid artery system in patients with TIA。 All patients were given ABCD2score,we test the levels of Hs-CRP of patients within24hours,and we give the ABCD2+Hs-CRP, records of patients after admission daily TIA seizure frequency, seizure duration, pay close attention to the patient’s condition changes,we give the patients vascular examination (CTA、MRA、DSA),then we analysis the level of stenosis, and analysis vascular stenosis distribution location All the patients with cerebral infarction as the end point, to seventh days after TIA as the endpoint of the observed time points, on progression of cerebral infarction patients with CT or MRI examination.We calculate the infarction volume, and witnin24hours we give the nervous system damage severity score(NIHSS).Results:Different risk classification in patients with TIA,its levels and positive rates were different (P<0.05); Different clinical outcomes in patients with high sensitivity C-reactive protein levels were different (P<0.05);Along with the ABCD2of the patients was elevated in patients with Hs-CRP numerical value, numerical presents the trend of escalation, high-risk group of patients with Hs-CRP levels rise highest, followed by a moderate risk group, low risk group of Hs-CRP increases the mini mum; different degree of stenosis in patients with high sensitivity C-reactive protein levels were different ((P<0.05);different parts of the internal carotid artery stenosis in patients with levels of high sensitivity C-reactive protein was no significant difference((P>0.05); ABCD2+Hs-CRP score in the evaluation of patients with TIA is better than ABCD2score in clinical outcome.Conclusion:Hs-CRP have certain connection with vascular stenosis severity, risk classification, clinical outcome outcome, and ABCD2score combinated Hs-CRPcan improve the clinical applicatio n value of ABCD2score, screening of high-risk TIA patients, to guide the clinical treatment.